Evidence map›Paper›PMID 40992012›Full record

ArticleDrug and alcohol dependence2025

A scoping review of interventions addressing social determinants of health and their influence on opioid use disorder outcomes.

Sarah J Cousins, Chunqing Lin, Yuhui Zhu, Sarah E Clingan, Larissa J Mooney, Layla Tondravi, Fei Wu, Yih-Ing Hser

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah J CousinsDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90024, United States. Electronic address: scousins@mednet.ucla.edu.
Chunqing LinDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90024, United States.
Yuhui ZhuDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90024, United States.
Sarah E ClinganDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90024, United States.
Larissa J MooneyDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90024, United States; VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, United States.
Layla TondraviDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90024, United States.
Fei WuLos Angeles County Chief Executive Office, Los Angeles, CA 90012, United States.
Yih-Ing HserDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90024, United States.

Funding

Greater Southern California Node of the Clinical Trials NetworkUG1DA049435 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YIH-ING HSER · 2019 to 2026
$16.7M
NIDA NIH HHS UG1 DA049435
6 · The paper itself

Abstract

backgroundOver the past decade, opioid overdose deaths have sharply increased. The Social Determinants of Health (SDOH) framework can guide interventions to improve opioid use disorder (OUD) outcomes. No comprehensive review of SDOH interventions and their impacts on OUD outcomes is available. This scoping review addresses that gap.

methodsWe extracted articles from PubMed, Embase, Web of Science, and Cochrane databases. Interventions were categorized according to SDOH domains: healthcare system, social and community context, neighborhood environment, economic stability, and education. Interventions and OUD outcomes (e.g., treatment initiation, opioid use, overdose) were summarized.

resultsTwenty-seven peer-reviewed studies targeted SDOH domains. The healthcare system domain (37 % of studies) was the most frequently addressed, focusing on provider training, access, and quality-of-care improvements with outcomes like increased initiation of medication for OUD, reduced opioid use, and reduced provider stigma. Community and social context (30 %) interventions included social support programs and community coalitions that reduced opioid use, overdose, and community-level stigma. Economic stability (16 %) interventions included employment-based reinforcements and financial incentives to promote abstinence. Neighborhood and physical environment (9 %) interventions included Housing-First initiatives that reduced opioid use. In the education domain (2 %), an early education intervention reduced adulthood OUD risk. Over half of all studies (52 %) used randomized designs; the remainder used quasi-experimental approaches. Gaps included a limited range of SDOH interventions, inconsistent definitions and measurements of SDOH, and a lack of rigorous evaluations.

conclusionFuture research should harmonize SDOH terminology and metrics, rigorously assess SDOH intervention outcomes, and expand the range of SDOH interventions.

Indexed as

Health DisparityOpioid Use DisorderSocial Determinants of HealthSubstance-Related DisorderUnited States

Identifiers

PMID40992012
PMCPMC12684375

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.