ArticleCell reports2025
E. coli-activated cellular circuit restrains intestinal inflammatory microbiota-specific T cells and protects against colitis.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages.Science immunology · 2026Article
- Targeted expression of the immunomodulatory peptide Scy by engineeredFrontiers in immunology · 2026Article
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Authors and funding
12 authors.
Funding
Abstract
Balance between microbiota-specific effector and regulatory T (Treg) cells is required to promote intestinal health and limit disease pathology. The pathways regulating T cell equilibrium during inflammation and the role of individual microbiota members in these outcomes are still being established. Here, we demonstrate that colonization with a single adherent-invasive Escherichia coli strain restrains pathogenic microbiota-directed T helper type 1 (Th1) cells. This results in a higher proportion of colon Treg cells, specifically tolerogenic microbiota-specific RORγt
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.