The Pain Is in the Brain With the Sugar-Coated Killer.

Abstract readReview

In one paragraph

Review in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Julia A MessinaDepartment of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-6411-198X

John R PerfectDepartment of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.

Funding

Pathobiology of C. neoformans in the Central Nervous SystemR01AI073896 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2008 to 2018

$4.4M

Evolution of Cryptococcus neoformans Strains from Patients with HIV/AIDSR01AI093257 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2011 to 2022

$3.8M

National Institute of Allergy and Infectious Diseases AI193257National Institute of Allergy and Infectious Diseases AI73896National Institute of Allergy and Infectious Diseases AI93257NIAID NIH HHS R01 AI073896NIAID NIH HHS R01 AI093257

6 · The paper itself

Abstract

Cryptococcus neoformans and Cryptococcus gattii are encapsulated yeasts that have become increasingly common central nervous system (CNS) pathogens within an enlarging populationof immunocompromised host. CNS disease represents a major interaction between the host and the yeast. In this regard, we have examined the myriads of tools that this group of yeasts possess that allow them to become very efficient pathogens in the human CNS, causing fatal meningoencephalitis if untreated. In the age of molecular approaches to the investiagion of fungal pathogenesis, cryptococcosis has been studied extensively at the genetic level, and there is an impressive array of virulence factors that this basidiomycetous pathogen has developed to cause disease. This review details a series of virulence factors and their pathways. There is also some appreciation of the complexity of the host responses, which are so essential to the outcome of these infections.

Indexed as

BrainCryptococcosisCryptococcus gattiiCryptococcus neoformansAnimalsHost-Pathogen InteractionsHumansImmunocompromised HostVirulence FactorsVirulence Factorscentral nervous system diseaseCryptococcusfungal pathologymeningoencephalitis

Identifiers

PMID40991722

DOI10.1093/infdis/jiaf496

PMCPMC12718010

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.