Evidence map›Paper›PMID 40991694›Full record

ArticleScience advances2025

Structural basis of

Kasper Holst Hansen, Mert Golcuk, Chang Hyeock Byeon, Abdulkadir Tunc, Emilie Buhl Plechinger, Morten K D Dueholm, James F Conway, Maria Andreasen, Mert Gur, Ümit Akbey

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. The microbiota-proteostasis axis: implications in neurodegenerative diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  3. Helical reconstruction of amyloids in cryoSPARC.Acta crystallographica. Section F, Structural biology communications · 2026
    Article
  4. A functional amyloid scaffold shapes insect egg coats.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kasper Holst HansenDepartment of Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0009-0000-4131-4821
Mert GolcukComputational Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-5476-8160
Chang Hyeock ByeonDepartment of Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-9997-7708
Abdulkadir TuncDepartment of Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0009-0006-7297-4316
Emilie Buhl PlechingerDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Morten K D DueholmDepartment of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.ORCID 0000-0003-4135-2670
James F ConwayDepartment of Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-6581-4748
Maria AndreasenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-6096-2995
Mert GurComputational Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-0983-4397
Ümit AkbeyDepartment of Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-3161-2969

Funding

Cryo-electron microscopeS10OD025009 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONWAY, JAMES F. · 2018 to 2018
$2.0M
Direct electron detecting (DED) cameraS10OD019995 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONWAY, JAMES F. · 2015 to 2015
$548k
NIH HHS S10 OD019995NIH HHS S10 OD025009
6 · The paper itself

Abstract

Biofilm-protected

Indexed as

AmyloidBacterial ProteinsBiofilmsPseudomonasPseudomonas aeruginosaCryoelectron MicroscopyMolecular Dynamics SimulationProtein ConformationAmyloidBacterial Proteins

Identifiers

PMID40991694
PMCPMC12459412

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.