Evidence map›Paper›PMID 40991690›Full record

ArticleScience advances2025

Liquid crystal-guided DNA information storage: Nondestructive recovery and long-term preservation.

Yi Zhang, Yangyi Liu, Li Miao, Huaxia Zhu, Yubin Ren, Kelu Zhao, Sikang Wan, Yawei Liu, Yang Yang, Chunhua Lu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Highly Secure In Vivo DNA Data Storage Driven by Genomic Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yi ZhangEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China.ORCID 0009-0009-4298-2181
Yangyi LiuCenter of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing, China.ORCID 0000-0003-0756-2498
Li MiaoDepartment of Stomatology, Seventh Medical Center of Chinese, PLA General Hospital, Beijing, China.ORCID 0009-0002-0805-2369
Huaxia ZhuEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China.
Yubin RenEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China.ORCID 0000-0002-2547-2165
Kelu ZhaoState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.ORCID 0009-0005-2247-1342
Sikang WanEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China.
Yawei LiuState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.ORCID 0000-0001-5032-3631
Yang YangInstitute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0002-2630-6062
Chunhua LuMOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, China.ORCID 0000-0001-7725-885X
Fan WangState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.ORCID 0000-0002-3351-8848
Xingyu JiangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.ORCID 0000-0002-5008-4703
Hongjie ZhangEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China.
Chunhai FanState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-7171-7338
Kai LiuEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China.ORCID 0000-0003-0878-5191

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA digital storage features high storage density, low power consumption, and extended digital recovery time. However, conventional DNA preservation methods suffer from limitations like low DNA loading and complex recovery processes. In this study, we develop a liquid crystal-guided DNA information preservation platform (LDIPP) assembled from diverse lengths of DNA molecules ranging from 688 base pairs to 4.8 mega-base pairs and cationic surfactants. The thermotropic LDIPP provides encoded DNA information with high density loading, thermoplasticity, antimicrobial, and anti-enzymatic properties. Notably, DNA information was nondestructively recovered by manipulating the assembly structure using specific salt solutions and bioamplified through microbial fermentation. By mineralizing inorganic crystals on LDIPP, the preservation lifetime is expected to be increased by nearly an order of magnitude at -20°C. The LDIPP platform offers enhanced DNA data loading, nondestructive recovery, and customizable macroscopic features, making it a promising option for long-term information preservation in the rapidly advancing field of DNA storage.

Indexed as

DNAInformation Storage and RetrievalLiquid CrystalsDNA

Identifiers

PMID40991690
PMCPMC12459424

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.