Evidence map›Paper›PMID 40991680›Full record

ArticleThe Journal of infectious diseases2026

The Changing Paradigm in Infectious Diseases-Host-Directed Medicine: Implications for the Next Generation of ID Physicians.

Jatin M Vyas, Simon Feys, Michael K Mansour, Joost Wauters, Frank L van de Veerdonk

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jatin M VyasVagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.ORCID 0000-0002-9985-9565
Simon FeysMedical Intensive Care Unit, Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-7516-9471
Michael K MansourDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Joost WautersMedical Intensive Care Unit, Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-5983-3897
Frank L van de VeerdonkDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-1121-4894

Funding

Control of Type I Interferon Production in Response to Candida albicansR01AI150181 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Jatin M Vyas · 2020 to 2026
$5.4M
In vivo Monitoring of Neutrophil Function in Patients after Stem Cell TransplantR01AI176658 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel Irimia, Charles P. Lin · 2023 to 2026
$3.2M
Pathways to Mentorship and Research: Training the Next Generation Physician-ScientistsR25AI147393 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2019 to 2024
$1.8M
MGH Next Generation Physician-Scientist Through Stimulating Access to Research in Residency Program (MGH-Next Gen StARR)R38HL150212 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2020 to 2023
$1.3M
MGH Diseases of Aging Pathway Via Stimulating Access to Research in Residency (MGH DAP StARR)R38AG070229 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BRADLEY T. HYMAN, Christine S Ritchie · 2023 to 2026
$1.1M
Geneva Foundation HU00012020011GileadHealthbook Company LtdMundiPharmaNIH HHS R01AI150181NIH HHS R01 AI176658NIH HHS R25AI147393NIH HHS R38AG070229NIH HHS R38HL150212Pfizer
6 · The paper itself

Abstract

The engagement of medical trainees to the field of infectious diseases has waned over recent years. While the reasons for this decline are multifactorial, one prominent concern is the perception that infectious disease specialists serve merely as gatekeepers of antibiotics. In this forward-looking perspective, we discuss a new paradigm for infectious diseases-host-directed therapies. Supported by the discovery of the mechanism of disease in many infectious diseases, coupled with the ever-expanding armamentarium of immune modulators, we envision that infectious disease physicians will soon be delivering immunotherapy coupled with antimicrobials to achieve cures that were previously impossible.

Indexed as

Communicable DiseasesInfectious Disease MedicinePhysiciansAnti-Bacterial AgentsHumansImmunotherapyAnti-Bacterial Agentsfungal infectionsID trainingimmunologyimmunotherapy

Identifiers

PMID40991680
PMCPMC13017740

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.