ArticlePLoS genetics2025
FaTRAB1, a bZIP transcription factor, enhances anthocyanin biosynthesis in strawberry leaves via tissue-specific regulation.
Article in PLoS genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Anthocyanin accumulation in fruit crops: a multi-layered regulatory network integrating molecular, epigenetic, hormonal and environmental regulation.Molecular biology reports · 2026Review
- Cyanidin-3-O-Glucoside: Biosynthetic Regulation, In Vivo Metabolism, and Anti-Tumor Mechanisms-An Integrated Study Based onPlants (Basel, Switzerland) · 2026Review
- The RCAR12-CAP1-OST1 module controls ABA-mediated stomatal closure in Arabidopsis.PLoS genetics · 2026Article
- Machine learning integrates metabolomics and proteomics to identify key regulators of anthocyanin biosynthesis in edible rose petals.Frontiers in plant science · 2026Article
- Molecular Mechanisms of Cold Stress Response in Strawberry and Breeding Strategies.Current issues in molecular biology · 2025Review
- Spatial and Temporal Dynamics of Phenylpropanoid Pathway-Derived Secondary Metabolites Under Abiotic Stress.Physiologia plantarumReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bZIP transcription factor FaTRAB1 has been extensively studied as a central regulator of plant adaptation to environmental stresses. However, its role in modulating anthocyanin biosynthesis remains unclear. This study reveals a novel function of FaTRAB1 in regulating anthocyanin accumulation in both strawberry leaves (Fragaria vesca 'Ruegen') and fruits (Fragaria × ananassa 'Benihoppe'). FaTRAB1 is a nucleocytoplasmic-localized protein, exhibiting relatively higher expression in leaves and small green fruits. Stable overexpression of FaTRAB1 in 'Ruegen' strawberry significantly enhanced anthocyanin levels in young, mature, and old leaves. Mass spectrometry and HPLC analysis identified three major anthocyanins in mature strawberry leaves: cyanidin-3-O-glucoside (C3G) and cyanidin-3,5-O-diglucoside (C3,5dG) (78.91%), and peonidin-3,5-O-diglucoside (Pg3,5dG, 12.6%), with pelargonidin-3-O-glucoside (Pg3G, 8.49%) as a minor component. Protein interaction assays demonstrated that FaTRAB1 likely competes with FabHLH3 for binding to FaMYB10 and FaTTG1, forming a novel regulatory complex that coordinately activates the promoter of anthocyanin structural genes (FaF3'H, FaANS, FaUFGT, and FaOMT). This mechanism preferentially promotes the accumulation of cyanidin derivatives (C3,5dG and C3G) in leaves, resulting in reddish-purple pigmentation, while Pg3,5dG and trace Pg3G contribute secondarily. In contrast, strawberry fruits predominantly accumulate Pg3G. Intriguingly, FaTRAB1 may slightly suppress FaMYB10/FaTTG1-mediated biosynthesis of Pg3G and cyanidin-based anthocyanins in fruits. Instead, it primarily enhances C3G accumulation through synergistic interaction with FaF3'H, leading to distinct pigmentation patterns between leaves and fruits. These findings elucidate the tissue-specific regulatory role of FaTRAB1 in strawberry anthocyanin accumulation, providing critical insights into organ-specific coloration mechanisms. This work establishes a theoretical foundation for improving strawberry color quality through targeted genetic manipulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.