ArticleProceedings of the National Academy of Sciences of the United States of America2025
A supporting-electrolyte-free four-compartment electrochemical reactor for aqueous and organic phase electrosynthesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Electrosynthesis offers a promising method to make valuable chemicals under mild conditions; however, its application has been greatly hampered by issues including the requirement of a supporting electrolyte, the limited solubility of reactant(s) in electrochemical compartments, the complex product(s) separation processes, etc. Herein, we innovatively present a four-compartment electrochemical reactor equipped with delicately designed active species diffusion membrane electrodes. Four compartments include two chemical (reduction and oxidation) compartments and two electrochemical (cathode and anode) compartments. The unique membrane electrodes physically separate the chemical compartments (containing organic reactants in pure solvent) from the electrochemical compartments (containing supporting electrolytes), while allowing electrosynthesis of high-value-added chemicals in both nonconducting aqueous and organic environments without the need of a supporting electrolyte. The reactor is able to drive both the anodic electrosynthesis (e.g., oxidation with a halogenation yield > 93%) and the cathodic electrosynthesis (e.g., reduction with a hydrogenation yield > 95% and a deuteration incorporation > 85%). The batch four-compartment electrochemical reactor can be engineered into a continuous type, where substrates in pure solvent can be converted into products with a conversion > 90% as they travel from the inlet to the outlet of the continuous reactor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.