Observational studyInterdisciplinary cardiovascular and thoracic surgery2025
Histological Analysis of Arterial and Venous Grafts Used in Coronary Bypass for Patients With Renal Insufficiency: A Prospective Multicentre Observational Study.
Observational study in Interdisciplinary cardiovascular and thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
objectivesChronic kidney disease (CKD) is associated with metabolic dysfunctions that accelerate atherosclerosis, posing significant challenges for patients undergoing coronary artery bypass grafting (CABG). In this population, arterial calcification and reduced saphenous vein patency are common complications. This multicentre prospective study aims to evaluate the impact of renal dysfunction on the histological characteristics of arterial and venous grafts used in CABG.
methodsVascular graft specimens collected during CABG were prospectively analysed and stratified into 3 groups based on renal function, according to established publications: Group 1 (glomerular filtration rate [GFR] ≥90 mL/min/1.73 m2), Group 2 (GFR 60-89 mL/min/1.73 m2), and Group 3 (GFR ≤59 mL/min/1.73 m2). Formalin-fixed samples were histologically assessed for intimal thickening (Grade 0-3), fibroelastosis, and vasa vasorum density.
resultsA total of 324 arterial grafts (Group 1: 100; Group 2: 134; Group 3: 90) and 289 vein grafts (Group 1: 86; Group 2: 119; Group 3: 84) were analysed, including 5 arterial and venous grafts from dialysis patients. No significant structural differences were observed between groups. Intimal thickening rates were comparable across renal function stages. Fibroelastosis was more prevalent in venous grafts (56%-64%) than in arterial grafts (10%-15%).
conclusionsThis study assesses graft histology in CABG patients stratified by renal function. At surgery, CKD does not appear to significantly alter graft structure. Further studies are warranted to explore long-term graft outcomes in this population.
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