Evidence map›Paper›PMID 40991171›Full record

ArticleDoklady. Biochemistry and biophysics2025

Preparation of 6-Azido-2-Chloropurine-2'-Deoxyriboside by Enzymatic Transglycosylation Reaction Catalyzed by Lactobacillus leichmannii Type II Nucleoside Deoxyribosyltransferase.

C S Alexeev, M A Konkina, N N Kurochkin, M S Drenichev

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Article in Doklady. Biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

C S AlexeevEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. micelle@mail.ru.
M A KonkinaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
N N KurochkinEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
M S DrenichevEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

6-azido-2-chloropurine-2'-deoxyriboside, a valuable precursor for the preparation of modified 2-chloropurine nucleosides substituted at the 6-position of the heterocyclic base, was obtained by enzymatic transglycosylation. 6-azido-2-chloropurine-2'-deoxyriboside can also be used as a photocross-linking agent to study the nucleic acids-proteins interactions. A type II nucleoside deoxyribosyltransferase from Lactobacillus leichmannii was used as a biocatalyst. The optimal conditions for the formation of 6-azido-2-chloropurine-2'-deoxyriboside using 7-methyl-2'-deoxyguanosine as a carbohydrate residue donor were determined.

Indexed as

DeoxyribonucleosidesLactobacillusPentosyltransferasesBiocatalysisGlycosylationDeoxyribonucleosidesnucleoside deoxyribosyltransferasePentosyltransferases6-azido-2-chloropurine7-methyl-2′-deoxyguanosineenzymatic transglycosylationmodified purinenucleoside deoxyribosyltransferasenucleosidesphotocross-linking agent

Identifiers

PMID40991171

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.