Evidence map›Paper›PMID 40991085›Full record

ArticleNeurochemical research2025

Banxia Shumi Decoction Improves Sleep and Neural Function in Insomnia Male Rats via BDNF/TrkB/CREB-Dependent Melatonin Signaling Activation.

Baojun Guo, Yuqin Tang, Yunjuan Wang, Qian Ma, Ying Wang, Yongqiang Zhang, Ranran Gao

Abstract read
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In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Baojun GuoDepartment of TCM, Henan Provincial People's Hospital, Zhengzhou University, No.7 Weiwu Road, Jinshui District, Zhengzhou, 450003, Henan, China.
Yuqin TangClinical Bioinformatics Experimental Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Yunjuan WangSchool of Life Sciences, Henan University, Kaifeng, 475004, Henan, China.
Qian MaClinical Bioinformatics Experimental Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Ying WangDepartment of Psychiatry, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Yongqiang ZhangHenan Academy of Medical Sciences, Zhengzhou, Henan, China.
Ranran GaoDepartment of TCM, Henan Provincial People's Hospital, Zhengzhou University, No.7 Weiwu Road, Jinshui District, Zhengzhou, 450003, Henan, China. syzyygrr@zzu.edu.cn.

Funding

Postdoctoral Research Project in Henan Province 335953
6 · The paper itself

Abstract

Insomnia seriously affects people's quality of life and health. Currently available insomnia medications demonstrate notable side effect profiles and lack well-established evidence regarding their sustained efficacy. The aim of this study was to investigate the efficacy of Banxia Shumi decoction (BXSMD) in insomnia and the molecular mechanism involved. The effect of BDNF/TrkB/CREB pathway on BSXMD treatment of insomnia was investigated by using p-chlorophenylalanine (PCPA) induced insomnia male rat model. The results of open field test, Morris water maze and hypnosis experiments implied that circadian dysrhythmia, increased open-field activity, decreased sleep quality and learning and memory impairments were observed in insomnia male rat. Besides, the levels of BDNF/TrkB/CREB pathway, 5-HT, MT, MT1 and MT2 were reduced, accompanied with neural tissue damage in insomnia male rats by ELISA, qRT-PCR, WB, immunohistochemistry and HE staining. BXSMD alleviated neural tissue damage and improved sleep quality along with cognitive functions (learning and memory) in insomnia male rats. Moreover, BXSMD caused activation of BDNF/TrkB/CREB pathway and upregulation of 5-HT, MT, MT1 and MT2 levels in insomnia male rats. BDNF overexpression-mediated activation of BDNF/TrkB/CREB pathway enhanced the pharmacological effects of BXSMD described above. Notably, MT1/MT2 antagonist attenuated the therapeutic effects of BXSMD on sleep disturbances and neural tissue damage in insomnia male rats, while BDNF knockdown in the hippocampus suppressed BXSMD-mediated activation of MT signaling, sleep enhancement, and neuroprotection. In summary, this study elucidated that BXSMD enhanced MT signaling by activating BDNF/TrkB/CREB pathway in the hippocampus, thereby ameliorating sleep disorders and neural damage in insomnia male rats.

Indexed as

Brain-Derived Neurotrophic FactorDrugs, Chinese HerbalMelatoninSleepSleep Initiation and Maintenance DisordersAnimalsCyclic AMP Response Element-Binding ProteinMaleRatsRats, Sprague-DawleyReceptor, trkBSignal TransductionBdnf protein, ratBrain-Derived Neurotrophic FactorCreb1 protein, ratCyclic AMP Response Element-Binding ProteinDrugs, Chinese HerbalMelatoninNtrk2 protein, ratReceptor, trkBBanxia shumi decoctionBDNF-TrkB-CREB pathwayInsomniaMelatonin

Identifiers

PMID40991085

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.