Evidence map›Paper›PMID 40991081›Full record

ArticleBulletin of experimental biology and medicine2025

Changes in Dendritic Spine Density and Morphology during Therapy with Acetylcholinesterase Inhibitors in a Mouse Model of Alzheimer's Disease.

G P Belyaev, K A Petrov, V E Semenov, I V Zueva

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

G P BelyaevArbuzov Institute of Organic and Physical Chemistry - Separated Division of Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia. gregoir4@gmail.com.
K A PetrovArbuzov Institute of Organic and Physical Chemistry - Separated Division of Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.
V E SemenovArbuzov Institute of Organic and Physical Chemistry - Separated Division of Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.
I V ZuevaArbuzov Institute of Organic and Physical Chemistry - Separated Division of Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed a comparative study of the effect of a new acetylcholinesterase inhibitor 1,3-bis[5-(o-nitrobenzylethylamino)pentyl]-6-methyluracil (C-35) and a commercial drug donepezil on the density and morphology of dendritic spines in the entorhinal cortex of transgenic APP/PS1 mice with a model of Alzheimer's disease. Administration of donepezil to transgenic mice did not significantly change spine density or morphology. In contrast, treatment with C-35 increased dendritic spine density by 56 and 34% in comparison with donepezil and the control group (untreated transgenic mice), respectively. This effect of C-35 was associated with an increase in the number of thin spines and a decrease number of stubby spines.

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsDendritic SpinesUracilAcetylcholinesteraseAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalDonepezilEntorhinal CortexHumansMaleMiceMice, TransgenicPiperidinesPresenilin-1AcetylcholinesteraseAmyloid beta-Protein PrecursorCholinesterase InhibitorsDonepezilPiperidinesPresenilin-1UracilAlzheimer’s diseasecholinesterase inhibitorsdendritic spinesmethyluracil derivatives

Identifiers

PMID40991081

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.