Evidence map›Paper›PMID 40991080›Full record

ArticleBulletin of experimental biology and medicine2025

Modified Method for Double Cannulation of Rat Bile Duct and Intestine for Pharmacokinetic Studies.

G A Frelikh, E A Yanovskaya, A P Lakeev, G A Chernysheva, V I Smolyakova

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

G A FrelikhGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
E A YanovskayaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. elena.yanovskaya@pharmso.ru.
A P LakeevGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
G A ChernyshevaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
V I SmolyakovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An improved method of cannulation of the bile duct and duodenum in rats has been developed to study the kinetics of medicinal compounds in the bile. The proposed double cannulation method ensures reliable fixation and accurate placement of the catheters, prevents their twisting and loss, and allows for a comprehensive study of the processes of substance absorption and elimination. The bile was collected from animals without anesthesia, the circulation of bile acids between the liver and intestine was preserved. This method has been tested in a study of the kinetics of 2,6-diisobornyl-4-methylphenol in rat bile over 24 h after oral administration (25 mg/kg in 0.5 ml of linseed oil). The pharmacokinetic profile of the substance has been shown to be a plateau with an indistinct maximum (216.87 ± 74.39 ng/ml, after 8 h), and its slow excretion with bile is observed.

Indexed as

Bile DuctsCatheterizationDuodenumAdministration, OralAnimalsBileBile Acids and SaltsIntestinal MucosaLiverMaleRatsRats, WistarBile Acids and Salts2,6-diisobornyl-4-methylphenolbilecannulationenterohepatic circulationpharmacokinetics

Identifiers

PMID40991080

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.