SynthesisBrain structure & function2025
The neurophysiology of healthy and pathological aging: a comprehensive systematic review.
Synthesis in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Before the task begins: linking resting-state gamma oscillations to face-name associative memory.Cognitive neurodynamics · 2026Article
- Brain Network Dynamics of Local and Global Predictive Processing in Aging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- FREQ-NESS Reveals Age-Related Differences in Frequency-Resolved Brain Networks During Auditory Recognition and Resting State.Annals of the New York Academy of Sciences · 2026Article
- EEG-based assessment of sustained attention in geriatric inpatients: a feasibility study.GeroScience · 2026Article
- Review
- Unlocking the Power of Plant-Derived Natural Products: Therapeutic Benefits for Cognitive Health and Neuropsychiatric Symptoms in Dementia-Related Diseases.Plants (Basel, Switzerland) · 2026Review
- Electroencephalographic phenotypes of postoperative delirium in the perioperative period.Journal of anesthesia and translational medicine · 2026Review
- AI-driven magnetoencephalography biomarkers in dementia risk prediction: current evidence, challenges and future perspectives.Frontiers in dementia · 2026Review
- Global scale-free brain activity as a potential neural signature of visual information processing in aging.Frontiers in aging neuroscience · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the population of older adults grows, so does the prevalence of neurocognitive disorders such as mild cognitive impairment (MCI) and dementia. While biochemical, genetic, and neuroimaging biomarkers have accelerated early detection and diagnosis, neurophysiological measures are absent from daily medical use. Electroencephalography (EEG) and magnetoencephalography (MEG) are two non-invasive techniques that measure neurophysiological signals in the brain and convey information about signal strength at different frequency bands, event-related activity, signal complexity, and temporal correlation between spatially remote brain regions. Here we conducted a pre-registered, comprehensive systematic review of 942 studies using EEG, MEG, and combined MEG and EEG to characterise the neurophysiology of healthy aging, MCI, and dementia under resting-state and task conditions. To complement our search, we also reviewed 51 past reviews in the field. Relevant features of these papers were extracted to present a detailed overview of the current state of evidence. Overall, neurophysiological measures show potential as diagnostic tools and could prove very valuable in predicting healthy and pathological aging trajectories. However, to reach this goal in clinical practice, it is crucial to adopt longitudinal designs, standardise methodologies, and identify biomarkers at the individual rather than group level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.