ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025
Risk factors for postoperative fever following cranioplasty in children: a retrospective cohort analysis.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify and quantify modifiable perioperative risk factors for early postoperative fever (POF) in children undergoing cranioplasty (CP), given that most early POF events are non‑infectious and contribute to longer hospitalization and increased healthcare costs.
methodsA retrospective single-center cohort of 216 pediatric CP patients (≤ 18 years, 2016-2024) was analyzed. Baseline variables included demographics, implant material, dural repair material, cranial defect size, and so on. Least Absolute Shrinkage and Selection Operator (LASSO) regression with tenfold cross-validation selected candidate predictors; multivariable logistic regression refined the model. Variables with statistically significant associations (p < 0.05) were used to build a nomogram. Model discrimination (C‑index), calibration, ROC curve, and decision curve analysis assessed predictive performance.
resultsPOF occurred in 71/216 patients (32.9%). Four variables were independent predictors: CP material (titanium mesh vs. polyetheretherketone [PEEK]: OR = 3.81, 95% CI 1.92-7.92, p < 0.001), dural repair material (synthetic patch vs. intact dura: OR = 7.57, 95% CI 2.45-25.42, p < 0.001; autologous tissue vs. intact dura: OR = 1.77, 95% CI 0.78-4.02, p = 0.171), subcutaneous drainage (with vs. without: OR = 0.29, 95% CI 0.12-0.66, p = 0.004), and cranial defect area (OR = 1.01 per cm
conclusionIn pediatric CP, use of titanium mesh, synthetic dural patches, absence of subcutaneous drainage, and larger cranial defect size are modifiable risk factors significantly associated with early POF. Preventive strategies focusing on implant and dural repair material selection, proactive drainage, and consideration of cranial defect size may reduce POF incidence and its clinical impact.
Indexed as
Identifiers
40991052What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.