Observational studyOral and maxillofacial surgery2025
Locoregional recurrence patterns in surgically treated stage III and IV oral squamous cell carcinoma: a prospective observational study.
Observational study in Oral and maxillofacial surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Prognostic factors analysis of patients with oral cavity squamous cell carcinoma.Brazilian journal of otorhinolaryngologyObservational
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvanced oral squamous cell carcinoma demonstrates high locoregional recurrence despite multimodal therapy. This study identified clinical and pathological predictors of recurrence in surgically treated stage III-IV OSCC.
methodsThis prospective observational study analyzed 260 patients with stage III-IV OSCC treated at a tertiary cancer center (2019-2021). Clinicopathological parameters including tumor staging, lymph node ratio, differentiation, margins, depth of invasion, extracapsular extension, lymphovascular invasion, perineural invasion and treatment factors were evaluated. Multivariate Cox regression identified independent predictors. ROC curve analysis determined optimal cutoffs.
resultsLocoregional recurrence occurred in 44/260 patients (16.92%). Univariate analysis revealed significant associations with LNR (p < 0.00001), ECE (p < 0.00001), LVI (p = 0.003), positive lymph nodes (p = 0.001), radiotherapy completion (p = 0.009), and surgery to radiation interval (p = 0.0002). Multivariate analysis identified three independent predictors: PNI (OR 18.42, 95% CI 5.43-62.46, p < 0.01), ECE (OR 8.17, 95% CI 1.51-44.33, p = 0.01), and positive node count (OR 1.64, 95% CI 1.21-2.22, p < 0.01). ROC analysis established ≥ 2 positive nodes as optimal cutoff (AUC = 0.844), stratifying patients into low-risk (< 2 nodes: 3.4% recurrence) and high-risk (≥ 2 nodes: 44.7% recurrence) groups. T-stage, margins, depth of invasion, and differentiation showed no significant association.
conclusionsPNI, ECE, and positive lymph node count independently predict locoregional recurrence in advanced OSCC. Our risk stratification model incorporating these factors enables personalized surveillance and adjuvant therapy intensification. Radiotherapy should commence within six weeks of surgery for optimal outcomes.
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