Evidence map›Paper›PMID 40990954›Full record

ReviewJournal of molecular cell biology2026

Regulated cell death in organ transplantation: recent developments and mechanistic overview.

Qian Chen, Jiashi Sun, Shifan Zhu, Minghui Wu, Hakjun Lee, Azeem Alam, Moradi Kimia, Enqiang Chang, Hailin Zhao, Yue Jin and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qian ChenDepartment of Anaesthesiology, Perioperative and System Medicine Laboratory, Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China.
Jiashi SunDepartment of Anaesthesiology, Perioperative and System Medicine Laboratory, Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China.
Shifan ZhuDepartment of Anaesthesiology, Perioperative and System Medicine Laboratory, Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China.
Minghui WuDepartment of Anaesthesiology, Perioperative and System Medicine Laboratory, Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China.
Hakjun LeeDepartment of Anaesthesiology, Perioperative and System Medicine Laboratory, Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China.
Azeem AlamDivision of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London SW7 2AZ, UK.
Moradi KimiaDepartment of Anaesthesiology, Perioperative and System Medicine Laboratory, Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China.
Enqiang ChangDivision of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London SW7 2AZ, UK.
Hailin ZhaoDivision of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London SW7 2AZ, UK.
Yue JinDepartment of Anaesthesiology, Perioperative and System Medicine Laboratory, Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China.
Daqing MaDepartment of Anaesthesiology, Perioperative and System Medicine Laboratory, Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China.ORCID 0000-0003-1235-0537

Funding

National Natural Science Foundation of China 81801900Zhejiang University School of Medicine CHZJU2024YS002
6 · The paper itself

Abstract

Organ transplantation is a definitive therapeutic option for patients with end-stage organ dysfunction and failure. Ischaemia-reperfusion (IR) injury is one of the leading causes of low graft utilization as it significantly increases the risk of primary graft dysfunction and acute rejection following transplantation. This risk is particularly high for organs obtained from donation after circulatory death (DCD) when compared with the organs from donation after brain death (DBD). IR injury exacerbates tissue damage via various mechanisms including the induction of regulated cell death. Regulated cell death and its consequences play critical roles in determining graft survival and function, thereby influencing the overall success of the transplant. Understanding the mechanisms underlying regulated cell death in IR injury is essential for developing therapeutic strategies to minimize tissue damage and improve clinical outcomes in organ transplantation. This review mainly discusses different types of regulated cell death and underlying mechanisms towards preventive cell death strategies in DBD and DCD organ transplantation in preclinical settings.

Indexed as

Organ TransplantationRegulated Cell DeathReperfusion InjuryAnimalsGraft RejectionGraft SurvivalHumansdonation after brain deathdonation after circulatory deathischaemia–reperfusionorgan transplantationregulated cell death

Identifiers

PMID40990954
PMCPMC12907733

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.