ArticleProtein science : a publication of the Protein Society2025
Protein-mediated electroporation: Pore formation in a calcium voltage-sensing domain induced by positive and negative nanosecond pulsed electric fields.
Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Protein-mediated electroporation: Pore formation in a calcium voltage-sensing domain induced by positive and negative nanosecond pulsed electric fields.Protein science : a publication of the Protein Society · 2025Article
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8 authors.
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Abstract
In this work, we investigate the conformational changes induced by a positive and negative nanosecond pulsed electric field (nsPEF) on the voltage-sensing domain (VSD) of a voltage-gated calcium channel. These conformational changes play a critical role in the formation of VSD pores. To formalize this phenomenon, we previously introduced the term protein-mediated electroporation. To explore this process, we conducted multiple Molecular Dynamics simulations using two electric field strengths:
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