Evidence map›Paper›PMID 40990860›Full record

ArticleTranslational vision science & technology2025

The Impact of Myopia on Regional Visual Field Loss and Progression in Glaucoma.

Anagha Lokhande, Luo Song, Yueyin Pang, Yan Luo, Louis R Pasquale, Sarah R Wellik, Carlos Gustavo De Moraes, Jonathan S Myers, Mohammad Eslami, Tobias Elze and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anagha LokhandeHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA.
Luo SongHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA.
Yueyin PangHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA.
Yan LuoHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA.
Louis R PasqualeEye and Vision Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sarah R WellikBascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA.
Carlos Gustavo De MoraesEdward S. Harkness Eye Institute, Columbia University Medical Center, New York, NY, USA.
Jonathan S MyersWills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Mohammad EslamiHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA.
Tobias ElzeHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA.
Lucy Q ShenMass Eye and Ear, Harvard Medical School, Boston, MA, USA.
Nazlee ZebardastHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA.
David S FriedmanMass Eye and Ear, Harvard Medical School, Boston, MA, USA.
Michael V BolandMass Eye and Ear, Harvard Medical School, Boston, MA, USA.
Mengyu WangHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA.

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
Personalizing Glaucoma Diagnosis by Disease Specific Patterns and Individual Eye AnatomyR01EY030575 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI ELZE, TOBIAS · 2019 to 2023
$2.4M
Glaucoma Risk Prediction Using Machine Learning Integration of Image-Based Phenotypes and Genetic AssociationsK23EY032634 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI ZEBARDAST, NAZLEE · 2021 to 2024
$1.0M
Relationship between Glaucoma and the Three-Dimensional Optic Nerve Head Related StructureR00EY028631 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI WANG, MENGYU · 2021 to 2023
$741k
Personalizing Circumpapillary Retinal Nerve Fiber Layer Thickness Norms for GlaucomaR21EY035298 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI WANG, MENGYU · 2023 to 2023
$557k
Sociodemographic predictors of healthcare utilization and adverse outcomes in Medicare beneficiaries with glaucomaR21EY032953 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI ZEBARDAST, NAZLEE · 2021 to 2022
$493k
NEI NIH HHS K23 EY032634NEI NIH HHS P30 EY003790NEI NIH HHS R00 EY028631NEI NIH HHS R01 EY030575NEI NIH HHS R21 EY032953NEI NIH HHS R21 EY035298
6 · The paper itself

Abstract

Purpose: The purpose of this study was to investigate the impact of myopia on regional visual field (VF) loss and progression in glaucoma. Methods: We included 112,633 24-2 VFs; longitudinal analyses comprised patients with at least 5 reliable VFs over 4 years. The degree of myopia was measured by spherical equivalent (SE) extracted from VF testing. Linear and Cox regressions determined the impact of myopia on regional VF loss and progression, respectively. We calculated three VF progression outcomes: (1) mean deviation (MD) progression: MD slope <0; (2) total deviation (TD) pointwise progression: at least 3 TD locations with TD slope ≤-1 decibels (dB)/year; (3) MD fast progression: MD slope ≤-1 dB/year (P value < 0.05). Longitudinal analyses were conducted for all subjects and with exclusion of patients with high myopia (SE ≤-6.00 diopters [D]). Results: More negative SE values were associated with worse TD values in the paracentral VF region (up to -0.14 dB/D). A more negative SE is associated MD (odds ratio [OR] = 0.95), TD pointwise (OR = 0.96), and MD fast progression (OR = 0.94; P < 0.001). Results were comparable when excluding patients with high myopia (P < 0.001): MD (OR = 0.95), VFI (OR = 0.95), and MD fast progression (OR = 0.94). Conclusions: Lower SE values are associated with worse paracentral VF loss. Worse myopia is associated with functional progression, even when excluding patients with high myopia. Translational Relevance: We provide evidence for the relationship between SE and VF progression and inform clinical practice by highlighting even mild myopia as a highly prevalent possible risk factor for glaucoma progression.

Indexed as

GlaucomaMyopiaVision DisordersVisual FieldsAdultAgedDisease ProgressionFemaleHumansIntraocular PressureLongitudinal StudiesMaleMiddle AgedVisual Field Tests

Identifiers

PMID40990860
PMCPMC12476162

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.