Evidence map›Paper›PMID 40990627›Full record

ArticleTechnology in cancer research & treatment

B7-H3 and CD39 Co-Localization in Gastric Cancer: A Potential Prognostic Biomarker and Potential Dual-Target for Immunotherapy.

Qiange Zhang, Ying Liu, Hanqin Xuan, Shenghua Zhan, Yu Shen, Ruipeng Wang, Siji Chen, Sisi Ding, Cuiping Liu, Lili Huang and 3 more

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Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qiange ZhangJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0009-0007-8169-8920
Ying LiuDepartment of Key Laboratory, Affiliated Changshu Hospital of Nantong University, Changshu, China.
Hanqin XuanDepartment of Pathology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Shenghua ZhanDepartment of Pathology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Yu ShenJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ruipeng WangJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Siji ChenDepartment of Clinical Laboratory, Tong Zhou Hospital of Chinese Traditional Medicine, Nantong, China.
Sisi DingJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Cuiping LiuJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Lili HuangDepartment of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.
Qi MaDepartment of Ultrasound, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Tingwang JiangDepartment of Key Laboratory, Affiliated Changshu Hospital of Nantong University, Changshu, China.
Lei CaoJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0000-0003-2378-8112

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntroductionGastric cancer (GC) is a highly heterogeneous malignancy, necessitating novel therapeutic targets. B7-H3 and CD39, as immune checkpoints, are potential modulators of the tumor microenvironment and may influence the efficacy of immunotherapies.MethodsB7-H3, CD39, and CD8 expression was assessed via immunohistochemistry (IHC) in 268 GC tissues and 80 gastric precancerous lesions. The correlation between B7-H3 and CD39 expression was analyzed using Spearman's correlation. Multiplex immunohistochemistry (m-IHC) was employed to determine the co-localization of B7-H3 and CD39 in GC tissues. Kaplan-Meier survival analysis and Cox regression models were utilized to evaluate clinical outcomes in different patient subgroups.ResultsBoth B7-H3 and CD39 expression showed a stepwise increase during gastric carcinogenesis including chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG), low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia (HGIN) to GC, with significantly higher expression levels in GC tissues compared to all precancerous lesions (

Indexed as

ApyraseB7 AntigensBiomarkers, TumorStomach NeoplasmsAdultAgedFemaleHumansImmunohistochemistryImmunotherapyKaplan-Meier EstimateMaleMiddle AgedNeoplasm StagingPrognosisTumor MicroenvironmentApyraseB7 AntigensBiomarkers, TumorCD276 protein, humanENTPD1 protein, humanB7-H3CD39dual-targetgastric cancerimmunotherapy

Identifiers

PMID40990627
PMCPMC12461060

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.