Evidence map›Paper›PMID 40990621›Full record

ArticleNeuropathology and applied neurobiology2025

Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin.

Max Anstötz, Sarah Tschirner, Caroline May, Steffen Kösters, Christine Martin, Svenja Caspers, Eleonora Aronica, Hans Jürgen Bidmon, Katrin Marcus, Carsten Korth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropathology and applied neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Max AnstötzInstitute of Anatomy II, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Sarah TschirnerDepartment of Neuropathology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Caroline MayCenter for Protein Diagnostics (PRODI), Medical Proteome Analysis, Ruhr-University Bochum, Bochum, Germany.
Steffen KöstersCenter for Protein Diagnostics (PRODI), Medical Proteome Analysis, Ruhr-University Bochum, Bochum, Germany.
Christine MartinInstitute of Anatomy II, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Svenja CaspersInstitute for Anatomy I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Eleonora AronicaDepartment of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Hans Jürgen BidmonInstitute of Neurosciences and Medicine, Structural and Functional Organisation of the Brain (INM-1), Forschungszentrum Jülich, Jülich, Germany.
Katrin MarcusCenter for Protein Diagnostics (PRODI), Medical Proteome Analysis, Ruhr-University Bochum, Bochum, Germany.
Carsten KorthDepartment of Neuropathology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0003-1503-1822

Funding

Bundesministerium für Bildung und Forschung (BMBF) 01GQ1422A
6 · The paper itself

Abstract

Proteomics of laser-dissected lipofuscin from aged, healthy brains reveals Palmitoyl-Protein Thioesterase 1 (PPT1) and other CLN proteins as constituents. PPT1 is increasingly sequestered to lipofuscin during ageing. Protein sequestering into lipofuscin may contribute to physiological neuronal ageing.

Indexed as

AgingBrainLipofuscinMembrane ProteinsNeuronal Ceroid-LipofuscinosesThiolester HydrolasesAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedProteomicsLipofuscinMembrane Proteinspalmitoyl-protein thioesterasePPT1 protein, humanThiolester Hydrolasesbrain ageingceroidlipofuscinlysosomeneuronal ceroid lipofuscinosisPalmitoyl‐Protein Thioesterase 1

Identifiers

PMID40990621
PMCPMC12459315

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.