ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Synergistic Promotion of Triple-Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella-Derived Glutamate and Platelet Activation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Gut-Mediated Systemic Toxicity of Micro- and Nanoplastics: Nanoscale Biointerface Properties, Microbiota-Metabolite Crosstalk, and Evidence Across Gut-Organ Axes.Nanomaterials (Basel, Switzerland) · 2026Review
- Emerging evidence on micro- and nanoplastics carcinogenicity: mechanisms, models, and signaling networks.Molecular cancer · 2026Review
- Synergistic Promotion of Triple-Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella-Derived Glutamate and Platelet Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Nanoplastics (NPs) are emerging environmental pollutants with potential health risks, yet their role in cancer progression remains poorly understood. Here, this is demonstrated that oral exposure to 100 nm polystyrene nanoplastics (PS-NPs) accelerates tumor initiation and metastasis in a murine triple-negative breast cancer (TNBC) model, without affecting primary tumor growth. PS-NPs do not directly alter TNBC cell behavior in vitro but induced gut microbiota dysbiosis, characterized by Alloprevotella enrichment and elevated systemic glutamate levels, both identified as key mediators of PS-NPs-driven tumor promotion. Moreover, PS-NPs enhanced platelet activation, evidenced by increased aggregation, microthrombus formation at metastatic sites, and upregulation of CD36 and Serpine1. Collectively, these findings uncover a synergistic mechanism whereby oral PS-NPs promote TNBC progression via a gut microbiota-derived metabolite-platelet axis, establishing an unrecognized link between environmental nanoplastic exposure and cancer progression, and highlighting potential therapeutic targets for intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.