ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Everyday functioning in young onset dementia: differences between diagnostic groups.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Everyday functioning in young onset dementia: differences between diagnostic groups.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Clinical staging in Swedish primary care using the Amsterdam Instrumental Activities of Daily Living Questionnaire.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Design and baseline findings of the NEODEM prospective cohort on early-onset neurodegenerative dementia.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
16 authors.
Funding
Abstract
backgroundThe aim of this study was to examine differences in Instrumental Activities of Daily Living (IADL) among young-onset dementia (YOD) diagnoses.
methodsParticipants were included from Amsterdam Dementia and Longitudinal Early-Onset Alzheimer's Disease (LEADS) cohorts, with diagnoses of typical Alzheimer's disease (AD), behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA), posterior cortical atrophy (PCA), or dementia with Lewy bodies (DLB) established in multidisciplinary meetings. We compared overall IADL scores and item level scores between groups using multiple regression analyses, adjusted for cohort, demographics, and disease severity.
resultsWe included 582 YOD patients (58.4 ± 4.2 years; 59%F), with overall moderate IADL problems (47.5 ± 8.57). DLB patients showed the most IADL difficulties (41.8 ± 7.8) compared to PCA, typical AD, bvFTD, and PPA (adjusted β range 4.62 to 14.14, all p < 0.01), whereas PPA patients showed the least IADL difficulties (55.8 ± 9.83), with item-specific differences.
conclusionWe found differences in everyday functioning between YOD types. Understanding IADL in YOD types will assist in care planning. HIGHLIGHTS: Patients with DLB showed the most IADL difficulties compared to PCA, typical AD, bvFTD, and PPA Patients with PPA showed the least IADL difficulties compared to DLB, PCA, typical AD, and bvFTD We identified diagnostic group-specific activity challenges. While 'working' was among the most commonly impaired activities across al groups, distinct functional challenges emerged per diagnosis: for example, DLB had high impairment in financial tasks, PCA patients in visual-spatial tasks, and bvFTD with planning and organizational activities (e.g. making appointments).
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