Herpes simplex virus diverts CIN85 endosomal cargo for exocytosis to evade antiviral responses: a novel role for the viral immediate-early protein ICP0.
Hope Waisner, Rabina Saud, Sarah Lasnier, Sreenath Muraleedharan Suma, Kim Foster-Lemieur, Maria Kalamvoki
Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors.
Hope Waisner *Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Rabina Saud *Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Sarah Lasnier *Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Sreenath Muraleedharan Suma *Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Kim Foster-Lemieur *Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Maria KalamvokiDepartment of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-7217-3571
Funding
Sex-specific effects of obestity on Influenza A virus infection and immunityP20GM130448 · NIGMS · KANSAS STATE UNIVERSITY · PI Igor Morozov · 2020 to 2026
$15.8M
Cargo, biogenesis and functions of extracellular vesicles released during HSV-1 infectionR01AI162784 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Maria Kalamvoki · 2021 to 2026
$2.4M
Super resolution microscope for the imaging core facilityS10OD023625 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NISHIMUNE, HIROSHI · 2019 to 2019
$987k
Spinning-Disk Confocal Microscope for Wide-Field, Super-Resolution, and Live-Cell ImagingS10OD032207 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SMITH, PETER G · 2022 to 2022
$600k
Alterations in the surfaceome of the herpes simplex virus 1 infected cells via the Cbl/CIN85 endocytic machinery and the role of the Infected Cell Protein No 0 (ICP0) in endocytosis.R21AI144883 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI KALAMVOKI, MARIA · 2020 to 2021
$421k
The One Ring to Rule Them All: How ICP0’s Ring Finger in Alliance with the Host Protein CIN85 Regulates Protein Trafficking and CommunicationF31AI186315 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Sarah Lasnier · 2024 to 2026
$76k
National Institute of Allergy and Infectious Diseases F31AI86315National Institute of Allergy and Infectious Diseases R01AI162784National Institute of Allergy and Infectious Diseases R21AI144883NIAID NIH HHS F31 AI186315NIAID NIH HHS R01 AI162784NIAID NIH HHS R21 AI144883NIGMS NIH HHS P20 GM130448NIGMS NIH HHS P20GM130448NIH HHS S10 OD023625NIH HHS S10 OD032207
6 · The paper itself
Abstract
Endocytosis and exocytosis pathways are critical for the survival of the cells. Viruses often hijack these trafficking pathways to support cell entry, replication, and egress and to evade host antiviral responses. The
Indexed as
Adaptor Proteins, Signal TransducingEndosomesExocytosisImmediate-Early ProteinsImmune EvasionUbiquitin-Protein LigasesAnimalsEndocytosisHost-Pathogen InteractionsHumansProtein BindingVirus ReplicationAdaptor Proteins, Signal TransducingImmediate-Early ProteinsSH3KBP1 protein, humanUbiquitin-Protein LigasesVmw110 protein, Human herpesvirus 1autophagyCIN85endosomesextracellular vesiclesHSV-1ICP0immunoevasioninnate immunity
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Herpes simplex virus diverts CIN85 endosomal cargo for exocytosis to evade antiviral responses: a novel role for the viral immediate-early protein ICP0. · full record | OpenQuestion