Evidence map›Paper›PMID 40990517›Full record

ArticleMicrobiology spectrum2025

Impact of multiplex polymerase chain reaction testing in patients with bacteremia.

Daisuke Kitagawa, Taito Kitano, Takehito Kasamatsu, Naoyuki Shiraishi, Mai Yasuda, Mai Okada, Soma Suzuki, Madoka Sekine, Ryo Yamanishi, Ayu Mukai and 7 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Daisuke KitagawaDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.ORCID 0000-0002-5352-8621
Taito KitanoDepartment of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan.ORCID 0000-0003-0623-066X
Takehito KasamatsuDepartment of Infectious Diseases, Nara Prefecture General Medical Center, Nara, Japan.
Naoyuki ShiraishiDepartment of Infectious Diseases, Nara Prefecture General Medical Center, Nara, Japan.
Mai YasudaDepartment of Pharmacy, Nara Prefecture General Medical Center, Nara, Japan.
Mai OkadaDepartment of Pharmacy, Nara Prefecture General Medical Center, Nara, Japan.
Soma SuzukiDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.
Madoka SekineDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.
Ryo YamanishiDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.
Ayu MukaiDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.
Ritsuki UejimaDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.
Yuki SuzukiDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara, Japan.ORCID 0000-0002-2509-8513
Akiyo NakanoDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara, Japan.ORCID 0000-0003-1379-384X
Ryuichi NakanoDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara, Japan.ORCID 0000-0003-2086-2591
Hisakazu YanoDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara, Japan.
Fumihiko NakamuraDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.
Koichi MaedaDepartment of Infectious Diseases, Nara Prefecture General Medical Center, Nara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid identification of pathogens in bacteremia is critical for optimizing antimicrobial therapy. The FilmArray blood culture identification 2 (BCID2) panel enables multiplex PCR-based detection of pathogens and resistance genes. This study aimed to evaluate the clinical impact of BCID2 implementation in hospitalized patients with bacteremia. To this end, we conducted a retrospective study at a single Japanese center (May 2018-December 2024). The outcomes included length of stay, in-hospital mortality, antimicrobial days of therapy (DOT), and days of antimicrobial spectrum coverage (DASC) score. The pre-BCID2 and BCID2 implementation periods were compared. Among the 2,872 patients with positive blood cultures, BCID2 implementation was associated with a significant reduction in mortality (adjusted odds ratio [aOR] 0.58, 95% CI: 0.37-0.92,

Indexed as

BacteremiaBacteriaMultiplex Polymerase Chain ReactionAgedAged, 80 and overAnti-Bacterial AgentsBlood CultureFemaleHospital MortalityHumansJapanLength of StayMaleMiddle AgedRetrospective StudiesAnti-Bacterial Agentsactive antimicrobial stewardship programs (ASP)antimicrobial days of therapy (DOT)bacteremiadays of antimicrobial spectrum coverage (DASC)FilmArray blood culture identification 2 (BCID2)

Identifiers

PMID40990517
PMCPMC12584631

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.