Evidence map›Paper›PMID 40990510›Full record

ArticleJournal of virology2025

GCN2 enhances host survival and drives eIF2α phosphorylation during mouse adenovirus type 1 infection.

Luiza A Castro Jorge, Daniel F Edwards, Rosario Labastida, Danielle E Goodman, Estela A Pereira, Oded Foreman, Katherine R Spindler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luiza A Castro JorgeDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-1595-3037
Daniel F EdwardsDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0009-0003-4781-0270
Rosario LabastidaDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0009-0001-7366-1729
Danielle E GoodmanDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-3033-9147
Estela A PereiraDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0009-0001-5281-4036
Oded ForemanDepartment of Pathology, Genentech Inc., South San Francisco, California, USA.ORCID 0000-0001-8197-3186
Katherine R SpindlerDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9829-6051

Funding

Viral interaction with host eIF2alpha kinasesR01AI133935 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPINDLER, KATHERINE R. · 2018 to 2022
$3.0M
NIAID NIH HHS R01 AI133935NIH HHS R01AI133935University of Michigan Medical School U081355
6 · The paper itself

Abstract

The integrated stress response (ISR) is a cellular signaling pathway that reduces protein synthesis in the face of cellular stress, including viral infection. Two eukaryotic initiation factor 2α (eIF2α) kinases, protein kinase R (PKR) and general control nonderepressible 2 (GCN2), are commonly activated during viral infections. Mouse adenovirus type 1 (MAV-1) infection leads to a steep reduction of PKR levels by proteasomal degradation. We assayed whether GCN2, a sensor of amino acid starvation and UV damage, plays a role in the ISR to MAV-1 infection. There was more phosphorylated GCN2 in MAV-1-infected cells, and its activation was dependent on virus replication since UV-inactivated virus was not able to increase the phosphorylation of GCN2. Infected

Indexed as

Adenoviridae InfectionsEukaryotic Initiation Factor-2MastadenovirusProtein Serine-Threonine KinasesAnimalseIF-2 KinaseHost-Pathogen InteractionsMiceMice, Inbred C57BLMice, KnockoutPhosphorylationVirus ReplicationEif2ak4 protein, mouseeIF-2 KinaseEukaryotic Initiation Factor-2Protein Serine-Threonine Kinasesgeneral control nonderepressible 2integrated stress responsePKRprotein kinase R

Identifiers

PMID40990510
PMCPMC12548416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.