ArticleInternational journal of surgery (London, England)2026
Efficacy of three-dimensional fast spin echo T2-weighted magnetic resonance imaging (Cube) for evaluating the longitudinal spread of perihilar cholangiocarcinoma after endoscopic biliary stenting: a diagnostic study.
Article in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough accurate assessment of the longitudinal tumor spread is vital for the resection of perihilar cholangiocarcinoma (PHC), endoscopic biliary stent (EBS) placement can make imaging difficult. This study evaluated the diagnostic performance of three-dimensional fast spin-echo T2-weighted MRI (Cube) compared with multidetector computed tomography (MDCT) for determining PHC extension before and after EBS placement.
methodsThis retrospective study included 91 patients who underwent surgical resection for PHC at a single center between 2016 and 2024 with available Cube and MDCT data. Four imaging scenarios were analyzed for each patient: MDCT without EBS, MDCT + EBS, Cube without EBS, and Cube + EBS. Radiological findings were compared with the pathological reference standard. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated for each scenario. Inter-reader agreement was determined using Cohen's kappa coefficient.
resultsMDCT without EBS showed 79.1% accuracy in defining tumor extension, which dropped significantly to 30.2% after EBS placement ( P < 0.0001). Cube imaging showed 77.3% accuracy without EBS and 70.7% accuracy with EBS, significantly higher than MDCT with EBS ( P < 0.0001). The evaluability rate of MDCT decreased from 98% to 37% after stenting, whereas Cube retained an 85% evaluability rate with EBS. The interreader agreement was moderate to substantial for MDCT without EBS ( κ = 0.74) and Cube without EBS ( κ = 0.72) but declined for MDCT with EBS ( κ = 0.34).
conclusionCube may be the preferred choice to guide surgical planning for PHC in patients without high-quality MDCT images before stent placement. Collectively, these findings suggest that Cube could bring about a paradigm shift in imaging-based diagnosis of PHC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.