Evidence map›Paper›PMID 40990477›Full record

ArticlemBio2025

A cyclic di-GMP phosphodiesterase in the VSP-2 island of

Aathmaja Anandhi Rangarajan, Kiwon Ok, Marissa K Malleck, Micah J Ferrell, Thomas V O'Halloran, Christopher M Waters

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aathmaja Anandhi RangarajanDepartment of Microbiology Genetics and Immunology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0003-3471-0257
Kiwon OkDepartment of Microbiology Genetics and Immunology, Michigan State University, East Lansing, Michigan, USA.
Marissa K MalleckDepartment of Microbiology Genetics and Immunology, Michigan State University, East Lansing, Michigan, USA.
Micah J FerrellDepartment of Microbiology Genetics and Immunology, Michigan State University, East Lansing, Michigan, USA.
Thomas V O'HalloranDepartment of Microbiology Genetics and Immunology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0001-8732-5059
Christopher M WatersDepartment of Microbiology Genetics and Immunology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0003-2336-7836

Funding

TR&D Project 3: Photoacoustic Detection of Metal Fluxes at the Tissue LevelP41GM135018 · NIGMS · NORTHWESTERN UNIVERSITY · PI JACOBSEN, CHRIS JOHNSON, O'HALLORAN, THOMAS V · 2020 to 2024
$5.8M
Metalloregulation by MerR and Fur Protein FamiliesR01GM038784 · NIGMS · NORTHWESTERN UNIVERSITY · PI O'HALLORAN, THOMAS V · 1992 to 2025
$3.5M
Exploring cyclic di-nucleotide signaling across the tree of life (Supplement)R35GM139537 · NIGMS · MICHIGAN STATE UNIVERSITY · PI WATERS, CHRISTOPHER M · 2021 to 2025
$2.9M
The contribution of novel cytidine deaminase regulatory systems to bacterial evolutionR01AI158433 · NIAID · MICHIGAN STATE UNIVERSITY · PI NEIDITCH, MATTHEW B, WATERS, CHRISTOPHER M · 2021 to 2025
$2.9M
Regulatory Roles of Zinc Fluxes in Metalloprotein Occupancy and Cell Cycle ProgressionR01GM115848 · NIGMS · NORTHWESTERN UNIVERSITY · PI O'HALLORAN, THOMAS V · 2015 to 2025
$2.8M
NIAID NIH HHS R01 AI158433NIGMS NIH HHS P41 GM135018NIGMS NIH HHS R01 GM038784NIGMS NIH HHS R01 GM115848NIGMS NIH HHS R35 GM139537NIH HHS P41 GM135018, R01GM038784, R01GM115848NIH HHS R35 GM139537, R01 AI158433
6 · The paper itself

Abstract

The second messenger cyclic di-GMP (cdG) is indispensable for the regulation of biofilm formation, motility, and a variety of other important bacterial behaviors in the majority of bacteria. The human pathogen

Indexed as

Gene Expression Regulation, BacterialGenomic IslandsPhosphoric Diester HydrolasesQuorum SensingVibrio choleraeZincBacterial ProteinsCyclic GMPBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPPhosphoric Diester HydrolasesZinccholeraecyclic di-GMPquorum sensingVibriozinc

Identifiers

PMID40990477
PMCPMC12607878

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.