Evidence map›Paper›PMID 40990453›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

An Interpretable SERS-AI Platform for Rapid and Quantitative Diagnosis of Polymicrobial UTIs: Powered by Positively Charged Plasmonic Nanoparticles and Attention-Based Deep Learning.

Zhonghua Shen, Linguo Xie, Yuwei Hou, Junjie Liang, Yuchi Jia, Haipeng Zhang, Zhenli Sun, Jingjing Du, Zeying He, Chunyu Liu and 1 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Explainable AI-SERS approach for highly accurate discrimination ofCurrent research in microbial sciences · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhonghua ShenKey Laboratory for Environmental Factors Control of Agro-product Quality Safety, Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin, 300191, China.
Linguo XieDepartment of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Yuwei HouDepartment of Radiology, Tianjin Beichen Hospital, Tianjin, 300400, China.
Junjie LiangDepartment of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Yuchi JiaDepartment of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Haipeng ZhangDepartment of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Zhenli SunMOE Key Laboratory of Resources and Environmental System Optimization, College of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, China.
Jingjing DuState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
Zeying HeKey Laboratory for Environmental Factors Control of Agro-product Quality Safety, Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin, 300191, China.
Chunyu LiuDepartment of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Wenjing LiuKey Laboratory for Environmental Factors Control of Agro-product Quality Safety, Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin, 300191, China.ORCID https://orcid.org/0000-0002-7559-5606

Funding

Agricultural Science and Technology Innovation Program CAAS-BRC-GLCA-2025-02Central Public-interest Scientific Institution Basal Research Fund Y2024QC29National Natural Science Foundation of China 42077299Natural Science Foundation of Tianjin Municipality 24JCYBJC00560Second Hospital of Tianjin Medical University 2023LC01Talent Support Program of Tianjin Institute of Urology MYSRC202313Talent Support Program of Tianjin Institute of Urology MYSRC202411
6 · The paper itself

Abstract

Polymicrobial urinary tract infections (UTIs) present diagnostic challenges due to overlapping symptoms and limitations of conventional methods. Although SERS and AI have shown potential for microbial diagnostics, existing approaches lack reproducibility, quantification capability, and interpretability-especially in complex clinical samples. Here, a label-free, interpretable SERS-AI platform for rapid identification and quantification of mixed urinary tract pathogens is proposed. A plasmonic substrate is engineered by combining Au@Ag core-shell nanoparticles with a positively charged bPEI surface, enabling electrostatic bacterial capture and stable SERS signal generation across diverse microbial mixtures. A convolutional neural network (CNN) enhanced with a convolutional block attention module (CBAM) to enable both accurate classification (95.8%, AUC  =  0.9774) and reliable bacterial proportion prediction (R

Indexed as

CoinfectionDeep LearningMetal NanoparticlesSpectrum Analysis, RamanUrinary Tract InfectionsHumansNeural Networks, Computerconvolutional block attention module (CBAM)convolutional neural network (CNN)mixed bacteriaproportionsurface‐enhanced Raman spectroscopy (SERS)

Identifiers

PMID40990453
PMCPMC12697763

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.