Evidence map›Paper›PMID 40990346›Full record

ArticleSleep2026

Circadian mechanisms underlying post-exercise blood pressure responses in healthy adults.

Leandro C Brito, Megan Jones, Nicole Chaudhary, George D Giraud, Steven A Shea, Saurabh S Thosar

Abstract read
In one paragraph

Article in Sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leandro C BritoOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, United States.ORCID 0000-0001-9902-7390
Megan JonesOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, United States.
Nicole ChaudharyOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, United States.
George D GiraudKnight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States.
Steven A SheaOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, United States.ORCID 0000-0003-1949-0954
Saurabh S ThosarOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, United States.ORCID 0000-0002-5075-4340

Funding

Endogenous circadian mechanisms underlying cardiovascular riskR35HL155681 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI STEVEN A SHEA · 2021 to 2026
$5.5M
Sleep and circadian mechanisms in hypertensionR01HL163232 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Saurabh Suhas Thosar · 2022 to 2026
$2.9M
American Heart Association-American Stroke Association 24CDA1267757Division of Consumer and Business Services of the State of Oregon ORS-656.630Division of Consumer and Business Services of the State of Oregon UL1-TR002369Medical Research Foundation of Oregon and American Heart Association Career Development 24CDA1267757NHLBI NIH HHS R01 HL163232NHLBI NIH HHS R35 HL155681NIH HHS R01-HL163232NIH HHS R35-HL155681
6 · The paper itself

Abstract

STUDY

objectivesWe aimed to determine whether the endogenous circadian system modulates blood pressure (BP) and its hemodynamic mechanisms during the post-exercise period.

methodsTen healthy adults (mean age: 24 ± 2 [SD] years; 4 males, 6 females) completed a 30-hour circadian protocol in dim light (<8 lux), while all behaviors and measurements were distributed across the 24-hour circadian cycle. Participants underwent five recurring 6-hour cycles of 2-hour sleep opportunities and 4-hour standardized wake episodes. After 90 minutes of awakening during each wake episode, participants performed 30 minutes of moderate-intensity aerobic exercise at 40% heart-rate-reserve. Systolic, diastolic, and mean BP and hemodynamic determinants derived from the beat-to-beat BP waveform (finger photoplethysmography) were measured just before and 30 minutes after the conclusion of each exercise bout. Arm and leg blood flows were assessed using vascular ultrasound. Endogenous circadian phases were determined using each participant's dim-light melatonin onset. Mixed-model cosinor analyses were used to test for the presence of circadian rhythmicity (with significance set at p<.05).

resultsPost-exercise systolic BP reduction and mean BP reduction had significant circadian rhythms, with the greatest decreases at the circadian phase corresponding to ~1 p.m. (-10 and -9 mmHg), respectively. Systemic vascular resistance and leg blood flow also had significant circadian rhythms, with the lowest resistance and greatest blood flow at ~11 a.m.

conclusionsIn young, healthy adults, the circadian system modulates the post-exercise BP reduction, likely due to skeletal muscle vasodilatory mechanisms.

Indexed as

Blood PressureCircadian RhythmExerciseAdultFemaleHealthy VolunteersHeart RateHemodynamicsHumansMaleMelatoninPhotoplethysmographyRegional Blood FlowYoung AdultMelatoninaerobic exercisecardiovascular healthcircadian rhythmspost-exercise hypotension

Identifiers

PMID40990346
PMCPMC12967256

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.