ArticleSleep2026
Non-rapid eye movement sleep and isoflurane-induced anesthesia show divergent subcortical connectivity patterns during transition phases in mice.
Article in Sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Characterizing transition state in mouse vigilance with electroencephalogram-electromyogram hypnodensity.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Anesthesia-Informed Approaches to Insomnia: Shared Neural Circuits, Biomimetic Sleep, and Emerging Interventional Strategies.Nature and science of sleep · 2026Review
- The ventrolateral preoptic nucleus: a multisystem integrator in sleep-wake regulation.Frontiers in neuroscience · 2026Review
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6 authors.
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Abstract
STUDY
objectivesNeural dynamics underlying anesthesia-induced unconsciousness are not fully understood. Given the parallels between natural sleep and anesthesia-induced unconsciousness, it becomes imperative to understand the neuronal mechanisms behind these two distinct yet seemingly interconnected states. This study investigated the interplay between sleep/wake-promoting nuclei during WAKE/non-rapid eye movement sleep (NREMS) transitions and the reversible loss and recovery of responsiveness (LOR/ROR) induced by isoflurane.
methodsLocal field potentials (LFPs) were recorded from the ventrolateral preoptic area (VLPO) and locus coeruleus (LC) in mice alongside chronic electroencephalogram-recordings. After baseline recordings, a slow induction regime of isoflurane anesthesia followed. Functional connectivity between VLPO and LC during NREMS, WAKE, LOR, and ROR was studied using coherence, inter-site phase clustering, and Granger causality analyses.
resultsLFP data revealed an increase in coherence between VLPO and LC during NREMS and a decrease during WAKE. Coherence decreased after LOR. During ROR, coherence did not change. Phase clustering between VLPO and LC increased during NREMS and decreased during WAKE, while across LOR/ROR transitions did not vary. Granger between VLPO and LC during WAKE/NREM transitions demonstrated bidirectional influences of the two nuclei. VLPO Granger caused LC during NREMS. In the slow-wave frequency, the Granger index from LC to VLPO decreased during NREMS, while after ROR, the Granger index from VLPO to LC increased.
conclusionsThe present study revealed functional connectivity patterns between VLPO and LC during sleep and isoflurane anesthesia, suggesting that these processes partly do not share similar functional connectivity patterns for the two nuclei.
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