ArticleSe pu = Chinese journal of chromatography2025
[Serum levels of polycyclic aromatic hydrocarbons and health risk assessment among children and adolescents].
Article in Se pu = Chinese journal of chromatography, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Polycyclic aromatic hydrocarbons （PAHs） are a class of persistent organic pollutants that are widely present in various environmental media such as air， soil， and water. They are highly environmentally stable and are mainly derived from combustion processes and industrial emissions. Although numerous studies have shown that PAHs are carcinogenic， mutagenic， and neurotoxic， their exposure levels and associated health risks in specific populations require further study. Children and adolescents are in a critical stage of growth and development， with immature physiological and immune systems， making them more sensitive to PAHs than adults. Hence， their internal exposure levels to PAHs and the associated health risks warrant particular attention. However， most of the existing studies have focused on adults， and there are relatively few studies on PAHs exposure in children and adolescents. Therefore， a total of 1 096 children and adolescents aged 6-18 years in a city located in western China were investigated. The concentrations of 12 PAHs in serum samples were simultaneously determined by solid-phase extraction coupled with gas chromatography-tandem mass spectrometry （SPE-GC-MS/MS）， and the effects of demographic characteristics， lifestyles， socioeconomic factors， and dietary habits on the concentrations of PAHs in serum were investigated using multiple linear regression models. The total estimated daily intake （TEDI） of PAHs was calculated based on their serum concentrations， and the hazard quotient （HQ） was derived using the reference dose （RfD） to evaluate non-carcinogenic health risk. Meanwhile， carcinogenic risk was evaluated based on the benzo［
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