Evidence map›Paper›PMID 40990108›Full record

ArticleMuscle & nerve2025

Feasibility of a Home-Based Exergaming Intervention for Youth With Spinal Muscular Atrophy.

Ihsane Iraqi, Pamela Ng, Xing Chen, Niamh Cushen, Juergen Gottowik, David Herzig, Shaainthabie Karthigesu, Danielle Levac, Alex MacKenzie, Jean K Mah and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ihsane IraqiDepartment of Neuroscience, McGill University, Montreal, Quebec, Canada.ORCID https://orcid.org/0009-0009-6923-970X
Pamela NgCentre for Outcomes Research and Evaluation, McGill University Health Centre Research Institute, Montreal, Quebec, Canada.
Xing ChenRoche Information Solutions, F. Hoffmann-La Roche AG, Basel, Switzerland.
Niamh CushenBC Children's Hospital, Vancouver, British Columbia, Canada.
Juergen GottowikRoche Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Basel, Switzerland.ORCID https://orcid.org/0000-0002-9695-572X
David HerzigRoche Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Basel, Switzerland.
Shaainthabie KarthigesuFaculty of Medicine, McGill University, Montreal, Quebec, Canada.
Danielle LevacSchool of Rehabilitation, University of Montreal, Montreal, Quebec, Canada.
Alex MacKenzieDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Jean K MahDepartment of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Slawomir OpalkaTransition Technologies PSC, Poland.
Beth PotterSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Kathryn SelbyDepartment of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Jordan SherikoDepartment of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.
Maureen SmithCanadian Organization for Rare Disorders, Ottawa, Ontario, Canada.
Sarah Turgeon-DesiletsSchool of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada.
Angelina WoofFaculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Maryam OskouiCentre for Outcomes Research and Evaluation, McGill University Health Centre Research Institute, Montreal, Quebec, Canada.ORCID https://orcid.org/0000-0003-1042-0108

Funding

CIHRF. Hoffmann-La Roche
6 · The paper itself

Abstract

INTRODUCTION/

aimsApproaches to optimize physical activity in youth with spinal muscular atrophy (SMA) are rapidly evolving. The primary objective of this study was to assess the feasibility of a fit-for-purpose home-based exergaming intervention in children and youth with SMA and peer controls.

methodsWe conducted a 4-week study at two Canadian sites to assess the feasibility of Tales from the Magic Keep, a home-based exergame specifically developed for youth with neuromuscular disorders that targets upper limb and trunk movements. Participants were asked to play the exergame for at least 20 min per session, 4 times a week for 4 weeks, and wear an accelerometer-based wearable device. Adherence, acceptability, and usability evaluations informed feasibility determinations. Adherence was quantified by gameplay frequency and duration. Acceptability and usability were assessed using study-specific questionnaires and the system usability scale (SUS).

resultsWe enrolled 12 participants, 8 of whom completed the study: 4 SMA (3 Type II, 1 Type III) and 4 controls. Among those 8, adherence was high, with an average of 4.5 and 3.5 sessions per week for the SMA and control groups respectively, and they found gameplay to be acceptable and enjoyable. The median score on the SUS was 68/100. The wearable device was generally well accepted; participants reported it as comfortable to wear and not interfering with daily activities. DISCUSSION: The exergame was feasible and acceptable in two thirds of participants. Iterative feedback obtained during this study led to subsequent updates to the game interface to optimize gameplay.

Indexed as

ExerciseExercise TherapyMuscular Atrophy, SpinalVideo GamesAdolescentChildFeasibility StudiesFemaleHumansMalePatient ComplianceWearable Electronic Devicesexergamingfeasibility studyneuromuscular disordersrehabilitationspinal muscular atrophy

Identifiers

PMID40990108
PMCPMC12599600

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.