Evidence map›Paper›PMID 40990072›Full record

ArticleMilitary medicine2026

Utility of Heart Rate Variability and Exertional Task Completion During Recovery of Mild Traumatic Brain Injury in Active Duty Service Members.

Julianna H Prim, Maria I Davila Hernadez, Wesley Cole, Amy S Cecchini, Shabbar I Ranapurwala, Karen L McCulloch

Abstract read
In one paragraph

Article in Military medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julianna H PrimDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, United States.
Maria I Davila HernadezDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, United States.
Wesley ColeDepartment of Exercise and Sports Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, United States.
Amy S CecchiniIntrepid Spirit Center, Womack Army Medical Center, Fort Bragg, NC 28310, United States.
Shabbar I RanapurwalaDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, United States.
Karen L McCullochDivision of Physical Therapy and Program for Human Movement Science, Department of Health Sciences, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7135, United States.ORCID 0000-0003-4228-0517

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
National Center for Advancing Translational Sciences (NCATS)NCATS NIH HHSNCATS NIH HHS UL1 TR001111NCATS NIH HHS UM1 TR004406NIHNIH HHS UL1TR001111
6 · The paper itself

Abstract

introductionPrimary care exertional testing is recommended for mild traumatic brain injury (mTBI) management in active duty service members (ADSM) before return-to-duty (RTD), yet there are no validated standardized tasks with objective physiological measures. Impairments to the automatic nervous system (ANS) after mTBI may last beyond symptom resolution and impact readiness for duty. Assessment of ANS functioning (heart rate variability, HRV) could provide an objective measure of mTBI recovery. MATERIALS AND

methodsEighteen ADSM with mTBI (2 weeks or less post-injury) and 18 age-matched healthy controls (HC) performed a protocol of two brief exertional tasks that challenge exertional and autonomic impairments: a 6-minute metronome-paced step-task and a 2-minute self-paced push-up task with built in rest periods. Heart rate variability components Respiratory Sinus Arrhythmia (RSA; parasympathetic input) and heart period (HP; average inter-beat-intervals), symptoms levels, and rate of perceived exertion (RPE) were measured prior, during, and after each task. All study procedures were approved by The U.S. Army Regional Health Command-Atlantic (RHC-A) IRB, #2019-001.

resultsBetween group analyses of self-rated and HRV components demonstrated mTBI differences: higher RPE during recovery (B = 1.0, P < .01); increased symptoms under exertion (χ2(1,36) = 5.14, P < .03); lower RSA at Rest 1 (B = -1.0, P = .04) indicating longer recovery; higher RSA during push-ups (B = 1.22, P = .02; and higher Heart Period during both step (B = 75.34, P < .02) and push-up task (B = 84.43, P < .01)) indicating less vagal withdrawal compared to HCs. ADSM with mTBI were less likely to successfully complete both tasks (OR = 5.80, [1.79-18.82]).

conclusionsThese brief exertional tasks may prove useful in primary care to identify symptomatic responses to exercise. Heart rate variability measurement may expose autonomic dysfunction that could influence readiness for full return to duty.

Indexed as

Brain ConcussionHeart RateMilitary PersonnelPhysical ExertionAdultExercise TestFemaleHumansMale

Identifiers

PMID40990072
PMCPMC12777512

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.