ArticleFrontiers in neurology2025
Transspinal stimulation preceding assisted step training reorganizes neuronal excitability and function of inhibitory networks in spinal cord injury: a randomized controlled trial.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Transspinal stimulation preceding step training reorganizes spinal locomotor circuits in human spinal cord injury: a randomized sham-controlled clinical trial.Frontiers in neural circuits · 2026Trial
- Cervical and thoracolumbar transspinal stimulation at 0.3 Hz and 30 Hz facilitates neuronal excitability in healthy humans: a randomized cross-over study.Experimental brain research · 2025Trial
- Transspinal direct current stimulation alters neuronal excitability but not homosynaptic inhibition in human spinal cord injury: a pilot clinical trial.Experimental brain research · 2025Trial
- Transspinal direct current stimulation as targeted therapy to increase motor neuron output and restore inhibition in human spinal cord injury.Frontiers in neurologyArticle
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4 authors.
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Abstract
Introduction: In this pilot randomized sham-controlled clinical trial, we characterized the spinal neuronal and network excitability in human spinal cord injury (SCI) when transspinal stimulation preceded locomotor training within the same session. Methods: Fourteen participants with chronic SCI received an average of 40 sessions with 30 Hz transspinal stimulation delivered for 30 min during standing (active: Results: Transspinal stimulation administered before locomotor training increased the amount of homosynaptic depression in the active-standing and active-supine groups, while presynaptic inhibition exerted on Ia afferent terminals increased in all study groups. Reciprocal Ia inhibition improved in the sham-standing and active-supine groups while in all groups the excitability threshold of soleus motoneurons decreased. Conclusion: This study demonstrated that transspinal stimulation preceding locomotor training partially restores some of the spinal inhibitory mechanisms acting presynaptic or postsynaptic, and produces network reorganization in chronic SCI. Noninvasive transspinal stimulation can increase the benefits of locomotor training, bringing spinal neuronal networks to a more functional state in chronic SCI.
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