ArticleFrontiers in immunology2025
Effect of the autoimmune-associated genetic variant
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- 3D Bioprinting Strategies in Autoimmune Disease Models.International journal of molecular sciences · 2025Review
- Preclinical Assessment in Transgenic NOD Mice of a Novel Immunotherapy for Type 1 Diabetes: Lipoplexes Down-Modulate the Murine C1858TInternational journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Recent evidence highlights neutrophils' role in initiating/sustaining aberrant immune responses in type 1 diabetes (T1D). The Materials and methods: Neutrophils were isolated from peripheral blood mononuclear cells (PBMCs) of wild-type (WT) C1858C, heterozygous (HET) C1858T T1D patients, and healthy controls (HD). Reactive oxygen species (ROS) levels were assessed using a fluorogenic probe by Fluorescence- Activated Cell Sorting (FACS) in tumor necrosis factor-alpha (TNF-α) primed, unprimed- Results: Neutrophil counts were increased in the female patients than in HD. ROS production was enhanced in the neutrophils of the HET patients Conclusion: Neutrophils from C1858T patients are more intrinsically active with increased ROS production and HUVEC adhesion/transmigration, suggesting enhanced contribution to the migration of other immunotypes from vessels into the pancreatic islets during T1D etiopathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.