ArticleComprehensive psychoneuroendocrinology2025
Phenomenon of hypocortisolism in individuals with obesity.
Article in Comprehensive psychoneuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Obesity has been associated with abnormalities of the hypothalamic-pituitary-adrenocortical (HPA)-axis. The aim of this study was to investigate patterns of cortisol stress reactivity and basal resting levels in individuals with obesity and healthy weight controls. Methods: Forty-seven individuals with obesity (BMI: 33.60 ± 4.09 kg/m Results: Obese low cortisol reactors demonstrated significantly lower basal cortisol resting levels compared to obese high cortisol reactors and healthy weight high/low cortisol reactors ( Conclusions: In conclusion, patterns of cortisol stress reactivity and basal resting levels were observed in the individuals with obesity but not in the healthy weight controls. The present data suggest that obesity may lead to the phenomenon of basal hypocortisolism.
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