ArticleMediators of inflammation2025
The Long Noncoding RNA, LOC645166, in T Cells of Ankylosing Spondylitis (AS) Patients Regulates the FOXP3 Expression via the Axis of LOC645166/miR-188-5p/NFKBID.
Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- An Increased Circular RNA, circRNPS1, in T Cells of Ankylosing Spondylitis Patients Enhances the MEK/ERK Signaling and Inflammation Mediated by T Cell Activation via Stabilization of hnRNPK and VAV1.International journal of molecular sciences · 2026Article
- Regulatory T cells in axial spondyloarthritis.Communications biology · 2026Review
- Targeting the nuclear factor kappa B pathway for the medical management of intervertebral disc degeneration.Frontiers in neuroscience · 2026Review
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6 authors.
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Abstract
The expression of long noncoding RNA (LncRNA), LOC645166, is downregulated in T cells of ankylosing spondylitis (AS) patients. The role of LOC645166 in contribution to AS pathogenesis was investigated. Here, we have identified that an interacting network of LOC645166/miR-188-5p/NF-κB inhibitor-D (NFKBID) occurs in T cells of AS patients and regulates the expression of forkhead box P3 (FOXP3). Downregulation of LOC645166 augments the levels of miR-188-5p that binds to the 3'-UTR of NFKB1D mRNA and blocks the NFKB1D expression. NFKB1D, also called IκB
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