ArticleInternational journal of clinical pediatric dentistry2025
Comparison of the Cytotoxicity of a Novel Obturating Material with Metapex for Pulpectomy in Primary Teeth Using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide Assay: An
Article in International journal of clinical pediatric dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Pulpectomy is a critical procedure for managing pulpally infected primary teeth. The choice of obturating material is important for the treatment's success. Metapex, a commonly used material, has several disadvantages such as rapid resorption and resistance issues against certain microorganisms. To overcome these disadvantages, a novel obturating material combining zinc oxide, calcium hydroxide, and metronidazole was developed. The aim of the study is to compare cytotoxic effects of the novel obturating material with Metapex using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Materials and methods: An Results: Both materials demonstrated minimal cytotoxicity at lower concentrations (2.5-10 µg/mL) and progressively higher cytotoxicity at increased concentrations (20-60 µg/mL). In the novel material group, significant differences were observed between 2.5 and 5 µg/mL ( Conclusion: The novel obturating material showed acceptable cytotoxicity at lower concentrations but exhibited higher cytotoxicity at increased levels. Further research is needed to optimize its composition for safe clinical use, particularly in pediatric patients. How to cite this article: Rajadurai MBR, Govindaraju L. Comparison of the Cytotoxicity of a Novel Obturating Material with Metapex for Pulpectomy in Primary Teeth Using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide Assay: An
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