ArticleInternational journal of clinical pediatric dentistry2025
The Combination of Biomimetic Materials Enhances the Functional Differentiation of Stem Cells Exfoliated from Human Deciduous Teeth.
Article in International journal of clinical pediatric dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Biomimetic scaffolds based on stem cells for neural tissue engineering: a review.Stem cell research & therapy · 2026Review
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7 authors.
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Abstract
Introduction: Stem cell therapy has been used in a variety of clinical procedures. When introduced into a specific part of the body, these cells differentiate into a target cell type and help replace damaged tissue and improve function. This experimental study was conducted to evaluate the effect of combining various natural biomimetic materials on stem cells from human exfoliated deciduous teeth (SHED). Materials and methods: After isolation and culturing of SHED to the fifth passage, cells were treated with a regular culture medium (Group I-negative control), osteoinduction medium (Group II-positive control), a combination of mineral trioxide aggregate plus coral (MC, group III), and a combination of Biodentine plus coral (BC, group IV). Viability was assessed using MTT assay on the 7th, 14th, and 21st days. Mineralization was evaluated by Alizarin Red S staining to detect calcium deposits at the same intervals. The anti-inflammatory potential for expression of MMP-9 and MMP-2 was analyzed using gelatin zymography. One-way ANOVA followed by Results: MC showed better cell viability than BC on the 14th and 21st days. However, BC demonstrated significantly better cytodifferentiation potential ( Conclusion: With the addition of coral, the properties of both commercially available biomimetic materials were enhanced, resulting in improved osteoinductive properties of mineral trioxide aggregate and Biodentine. The MC combination showed better cell viability and proliferation, while BC showed superior cytodifferentiation and anti-inflammatory properties. Coral, as a natural material, enhanced both formulations significantly. How to cite this article: Dahake PT, Bhamare S, Kale YJ,
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