Evidence map›Paper›PMID 40989941›Full record

ArticlePlastic and reconstructive surgery. Global open2025

Complex Wound Reconstruction in a Patient With Ehlers-Danlos Syndrome.

Sohayla Rostami, Tomer Lagziel, Stephanie Lynne Martinez, Qingwen Kawaji, Charles Scott Hultman, Mark E Lavallee

Abstract readCase Reports
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sohayla RostamiFrom the Department of Plastic and Reconstructive Surgery, Johns Hopkins University Medical Center, Burn Unit, Bayview Campus, Baltimore, MD.
Tomer LagzielFrom the Department of Plastic and Reconstructive Surgery, Johns Hopkins University Medical Center, Burn Unit, Bayview Campus, Baltimore, MD.
Stephanie Lynne MartinezFrom the Department of Plastic and Reconstructive Surgery, Johns Hopkins University Medical Center, Burn Unit, Bayview Campus, Baltimore, MD.
Qingwen KawajiFrom the Department of Plastic and Reconstructive Surgery, Johns Hopkins University Medical Center, Burn Unit, Bayview Campus, Baltimore, MD.
Charles Scott HultmanFrom the Department of Plastic and Reconstructive Surgery, Johns Hopkins University Medical Center, Burn Unit, Bayview Campus, Baltimore, MD.
Mark E LavalleeDepartment of Orthopedics/Sports Medicine, Sports Medicine of Central PA-UPMC, Harrisburg, PA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ehlers-Danlos syndrome (EDS) is a hereditary condition marked by collagen defects leading to tissue fragility throughout various body systems. One notable challenge for patients with EDS is compromised wound healing due to connective tissue fragility. This study described the case of a 53-year-old man with classical type EDS, presenting with a significant wound over his left knee, following numerous complications after a patellar tendon rupture. Traditional healing methods, including a gastrocnemius flap, were of limited benefit due to the patient's EDS condition. A novel surgical approach, involving the use of a split-thickness skin graft combined with the Recell Autologous Skin Cell Harvesting Device, resulted in successful wound healing. Ten months postsurgery, the patient demonstrated excellent graft adherence without any complications. This case indicates the potential benefits of the split-thickness skin graft and Recell method for patients with EDS, offering an effective treatment modality for significant wound healing challenges in this population.

Identifiers

PMID40989941
PMCPMC12453333

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.