ReviewInternational journal of nanomedicine2025
Nanocrystalline Drug Delivery Systems for Natural Compounds: Progress, Challenges and Future Opportunities.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- RAGE Signalling in Acute Inflammatory Disorders: Therapeutic Potential of Natural Products.Biomolecules · 2026Review
- Recent advances in the detection and treatment of hydatid cysts by nanomaterial-based carriers.Iranian journal of basic medical sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herbal medicines, under the guidance of Traditional Chinese medicine (TCM) theory, have played an irreplaceable role in treating and controlling various diseases for centuries. However, both traditional and contemporary TCM formulations are plagued by drawbacks such as complex preparation processes, poor stability, and the inconvenience of water decoction. Moreover, natural active ingredients derived from TCM, despite their definite physicochemical properties and significant therapeutic potential-exemplified by the anticancer effects of terpenoids like paclitaxel and tretinoin, and the antihypertensive properties of flavonoids including artemisinin and quercetin-face substantial hurdles in clinical translation due to poor aqueous solubility, low bioavailability, and potential toxicity. Nanocrystalline drug delivery systems (NCDDS) have emerged as a versatile strategy to address these limitations, leveraging the unique properties of nanocrystals to enhance drug dissolution, improve bioavailability, and enable targeted delivery. This review synthesizes recent advancements in NCDDS for natural compounds, elaborating on the current cutting-edge status of preparation techniques and characterization methods, as well as key progress in enhancing the in vitro and in vivo efficacy of natural agents, including terpenoids, flavonoids, and polyphenols. Despite these accomplishments, several challenges persist, such as inadequate colloidal stability, obstacles in scaling up production, and potential long-term toxicity concerns. Future opportunities are centered on the development of advanced nanocrystal preparation technologies, integration with multifunctional modification techniques, and exploration of interdisciplinary cross-applications. The objective of this review is to offer insights into the current landscape of NCDDS for natural compounds and to guide further research efforts toward addressing existing challenges, thereby expediting their clinical translation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.