Evidence map›Paper›PMID 40989859›Full record

ArticleAnnals of surgery open : perspectives of surgical history, education, and clinical approaches2025

Impact of Perioperative Hemoglobin A1c Levels on Survival Outcomes of Patients With Pancreatic Cancer: A Retrospective Study.

Hidemasa Kubo, Katsuhisa Ohgi, Shimpei Otsuka, Yuta Okawa, Ryo Ashida, Mihoko Yamada, Yoshiyasu Kato, Hideyuki Dei, Katsuhiko Uesaka, Akifumi Notsu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hidemasa KuboFrom the Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Katsuhisa OhgiFrom the Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Shimpei OtsukaFrom the Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Yuta OkawaDivision of Endocrinology and Metabolism, Shizuoka Cancer Center, Shizuoka, Japan.
Ryo AshidaFrom the Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Mihoko YamadaFrom the Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Yoshiyasu KatoFrom the Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Hideyuki DeiFrom the Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Katsuhiko UesakaFrom the Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Akifumi NotsuClinical Research Center, Shizuoka Cancer Center, Shizuoka, Japan.
Teiichi SugiuraFrom the Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to clarify the association between perioperative hemoglobin A1c (HbA1c) levels and survival outcomes in pancreatic cancer (PC) patients. Background: Diabetes mellitus is frequently associated with PC and may affect survival outcomes. Methods: We retrospectively analyzed 569 patients who underwent pancreatectomy for PC with available preoperative HbA1c (HbA1c-pre) data (2002-2018). A subgroup analysis included 318 patients with HbA1c measured 1 year postsurgery (HbA1c-1Y). Results: Optimal cutoff values were 9.0 for HbA1c-pre and 10.0 for HbA1c-1Y. Patients with HbA1c-pre ≥9.0 had worse relapse-free survival (RFS; median, 11.8 vs. 16.3 months, Conclusions: HbA1c-pre ≥9.0 and HbA1c-1Y ≥10.0 were prognostic factors in PC. Postoperative follow-up for diabetes mellitus is important, particularly following DP.

Indexed as

hemoglobin A1cpancreatic cancer

Identifiers

PMID40989859
PMCPMC12453312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.