Evidence map›Paper›PMID 40989834›Full record

ArticleMaterials today. Bio2025

Photothermal-triggered NO-releasing nanofiber membrane mitigates intervertebral disc degeneration via inflammation inhibition and matrix stabilization.

Guanfeng Huang, Jiajun Xie, Jialan Chen, Jiangminghao Zhao, Pinkai Wang, Jian Zhang, Peichuan Xu, Yang Li, Xiaolong Chen, Xinxin Miao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guanfeng HuangDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Jiajun XieDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Jialan ChenDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Jiangminghao ZhaoDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Pinkai WangDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Jian ZhangDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Peichuan XuDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Yang LiDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Xiaolong ChenDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Xinxin MiaoDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Wei XiongDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Xigao ChengDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc-related low back pain represents a major source of chronic pain. Due to the inflammatory microenvironment and impaired extracellular matrix (ECM) synthesis in intervertebral disc degeneration (IVDD), annulus fibrosus (AF) injuries have limited healing capacity. Effective AF repair thus requires modulation of the inflammatory state, promotion of ECM deposition, and enhancement of cellular migration. In this study, we developed a multifunctional photothermal nanofibrous membrane system by electrospinning biocompatible chitosan (CS) and polyvinyl alcohol (PVA) integrated with the photosensitizer polyaniline (PANI) and the nitric oxide (NO) donor S-nitrosoglutathione (GSNO). The system enables mild photothermal therapy (MPTT)-NO synergy via NIR-triggered photothermal heating and controlled NO release. Under NIR irradiation, the generated mild heat induces AF cells to upregulate heat shock proteins (HSPs), thereby enhancing tissue repair. Furthermore, leveraging the thermosensitive release of NO from GSNO, PVA-CS-PANI-GSNO achieves spatiotemporal NO delivery under NIR control, which acts synergistically with MPTT to suppress inflammatory cytokine expression, promote ECM remodeling, and inhibit apoptosis of AF cells, ultimately facilitates the repair of the AF. By overcoming the limitations of systemic anti-inflammatory therapies imposed by the avascular nature of the AF, this strategy offers a promising avenue for the treatment of AF injuries associated with IVDD.

Indexed as

Annulus fibrosus injuryMild photothermal therapyNanofibrous membraneNitric oxide gas therapy

Identifiers

PMID40989834
PMCPMC12451378

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.