ArticleFrontiers in nutrition2025
Analysis of the association between dietary sodium intake and cognitive function: a NHANES-based machine learning study and animal experimental validation.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Animal models of multi-infarct dementia: Methodological approaches, neuropathology, functional outcomes, and translational relevance.Experimental neurology · 2026Review
- Impact of High Dietary Salt on Neurovascular and Cognitive Functions.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Predictors of cognitive resilience in the old-old: An observational study using real-world electronic health record data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
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Authors and funding
7 authors.
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Abstract
Background: Sodium intake is undoubtedly essential for normal bodily function, but it is an important public health concern when intake exceeds dietary requirements. With salt intake exceeding recommended levels in almost all countries, high salt intake has become an important global health topic. This study aimed to be the first to combine epidemiological big data with animal behavioral experiments to systematically investigate the association between dietary sodium intake and cognitive function. Methods: Based on NHANES data from 2011 to 2014, the association between dietary sodium intake and cognitive impairment was assessed using multivariate linear regression and five types of machine learning, including random forest and XGBoost, in 2367 participants aged 60-80 years. Cognitive function was further assessed by a 6-month high-salt dietary intervention in a C57BL/6 mouse model combined with behavioral tests such as the Morris water maze and Open Field Test (OFT). Results: The results of the study revealed that the average daily sodium intake of the 2,367 middle-aged and older adults included reached 4,502 mg, with 91% exceeding the recommended standard. Dietary sodium intake was positively correlated with cognitive function scores ( Conclusion: There was a threshold-dependent association between dietary sodium intake and cognitive function, and the dose-response trend was consistent between human observational studies and animal studies. This study provides translational medical evidence for the public health strategy of "salt reduction for dementia prevention.
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