ArticleERJ open research2025
Feasibility and acute physiological responses to supramaximal high-intensity interval training in COPD: a randomised crossover trial.
Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acute Cytokine Responses to High-Intensity Intermittent Exercise in Humans: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Exercise-induced gut microbiota metabolites and the gut-lung axis: implications for chronic obstructive pulmonary disease.Journal of thoracic disease · 2026Review
- The modified Borg cycle strength test (mBCST): Feasibility and physiological response in people with COPD and healthy older adults.Experimental physiology · 2026Article
- Development of a Bedside Decision Tree for Postexacerbation Risk Stratification: Translating Neuroimmune Biomarker Dynamics Into Clinical Practice.Canadian respiratory journal · 2026Observational
- Pushing the limits: does suprahigh-intensity interval training open a new frontier in pulmonary rehabilitation?ERJ open research · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Extrapulmonary manifestations, including cognitive impairment and reduced muscle and cardiovascular function is common in COPD. While high-intensity exercise offers extrapulmonary benefits, its implementation in COPD is challenging. This randomised crossover trial examined the feasibility and physiological responses of a novel supramaximal high-intensity interval-training (SupraHIIT) protocol compared with moderate-intensity continuous training (MICT) in people with COPD and matched healthy controls (HCs). Methods: 16 people with COPD and 16 HCs performed SupraHIIT and MICT. SupraHIIT consisted of ten 6-s intervals at ≈150% and ≈200% of maximum aerobic power (MAP), while MICT was performed for 20 min at 60% of MAP. Outcomes were exercise intensity, change in exerkines, feasibility and cardiorespiratory demand of the modalities. Results: SupraHIIT was feasible and enabled up to a 3.5-fold increase in external exercise intensity compared with MICT (184±66 and 245±88 Conclusion: In COPD, short-duration SupraHIIT is more feasible and enables markedly higher external exercise intensities than MICT. By elevating pBDNF and other potentially beneficial exerkines, it shows potential for extrapulmonary benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.