ArticleTransboundary and emerging diseases2025
Whole-Genomic Characterization of Two Different PRRSV-1 Strains Isolated From a Single Pig.
Article in Transboundary and emerging diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Characterization and pathogenicity of single-farm-isolated PRRSV 1 and PRRSV 2 strain in China.Virulence · 2026Article
- Molecular and pathological characteristics of co-infection with PRRSV-1 and PRRSV-2 recombinant strains in a pig farm in Xinjiang, China.BMC veterinary research · 2026Article
- Genetic and Pathogenic Characteristics of Novel PRRSV-1 Strain CH-JX-2504 and CH-SDTA-2506 in China.Transboundary and emerging diseases · 2026Article
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23 authors.
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Abstract
Recent studies have demonstrated that porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) strains isolated from different farms in China have significant genomic heterogeneity, whereas strains from the same farm present a high degree of genomic similarity. In this study, primary alveolar macrophages (PAMs) and high-throughput sequencing technology were used to successfully isolate and characterize two different PRRSV-1 strains (designated TZJ3556-1 and TZJ3556-2) in a single pig from a farm in Shandong Province with a PRRSV-1 outbreak. Phylogenetic analysis based on ORF5 and complete genome sequences revealed that both TZJ3556-1 and TZJ3556-2 belong to the BJEU06-1-like subgroup. Nucleotide (nt) sequence alignment revealed that the pairwise genomic similarity between TZJ3556-1 and TZJ3556-2 was only 86.03%. Additionally, both strains exhibited the characteristic 5 (4+1) discontinuous amino acid (aa) deletion in the Nsp2 region. Recombination analysis revealed that TZJ3556-1 is one of the parental strains for the recombinant strain TZJ3556-2, contributing Nsp1β, partial Nsp2, partial ORF4, and ORF5-3'UTR genes. This study reports, for the first time, coinfection with multiple PRRSV-1 strains in a single pig and the emergence of an intrasubgroup recombinant strain within the BJEU06-1-like subgroup. The genetic diversity of PRRSV-1 strains in China is likely to become increasingly complex, and these strains may have overcome physical barriers between farms. The emergence of complex and diverse PRRSV-1 strains poses a serious challenge for the prevention and control of PRRS in China.
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