Evidence map›Paper›PMID 40989730›Full record

ArticleFrontiers in plant science2025

Multi-omics analysis reveals ThMYB6 regulation of flavonoid biosynthesis in differently colored tuberous roots of

Feng Yang, Qiaoyue Xing, Shouzan Liu, Yiwen Gu, Ziyue Wang, Hongyan Wang, Qiong Shen, Shan Li, Bojie Feng, Yan Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Amendment Bridges Habitat-Driven Quality Gaps inPlants (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Feng Yang *National Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang Agriculture and Forestry University, Hangzhou, Zhejiang, China.
Qiaoyue Xing *National Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang Agriculture and Forestry University, Hangzhou, Zhejiang, China.
Shouzan LiuBotanical Garden, Zhejiang A&F University, Hangzhou, Zhejiang, China.
Yiwen GuCollege of Food and Health, Zhejiang A&F University, Hangzhou, Zhejiang, China.
Ziyue WangNational Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang Agriculture and Forestry University, Hangzhou, Zhejiang, China.
Hongyan WangNational Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang Agriculture and Forestry University, Hangzhou, Zhejiang, China.
Qiong ShenNational Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang Agriculture and Forestry University, Hangzhou, Zhejiang, China.
Shan LiNational Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang Agriculture and Forestry University, Hangzhou, Zhejiang, China.
Bojie FengGeneral Station of Zhejiang Forestry Extension, Hangzhou, Zhejiang, China.
Yan BaiNational Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang Agriculture and Forestry University, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: We employed integrated metabolomic and transcriptomic analyses to compare the two root types. Key candidate genes were cloned and functionally characterized to uncover the regulatory mechanisms involved. Results: Metabolomic analysis identified significant changes in 217 metabolites between the two types, among which 57 flavonoids, such as Hesperetin-7-O-glucoside, were significantly higher in the yellow-brown roots. Transcriptomic analysis revealed 3516 differentially expressed genes, many associated with flavonoid biosynthesis. Differences in root quality were largely attributed to varied flavonoid production. Analysis of transcription factors regulating this process identified a strong correlation between Conclusion: The ThMYB6-mediated divergence in flavonoid biosynthesis is the key factor influencing quality differences between the two phenotypes. These results establish a theoretical foundation for targeted quality improvement and offer scientific support for the medicinal development of

Indexed as

flavonoidsmetabolomemolecular mechanismMYB factorTetrastigma hemsleyanumtranscriptome

Identifiers

PMID40989730
PMCPMC12450873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.