ArticleInfection and drug resistance2025
Lymphocyte Profile Analysis in Lymph Node Puncture Fluid of Mediastinal Reactive Lymphadenopathy and Its Value in Differential Diagnosis with Tuberculous Lymphadenitis.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lymphocyte profile (LP) analysis in mediastinal lymph nodes for differentiating reactive lymphadenopathy (RL) from tuberculous lymphadenitis (TBLA) remains understudied. Methods: Patients with intrathoracic lymphadenopathy undergoing endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) were enrolled. Lymph node puncture fluid (LNPF) was analyzed via flow cytometry to compare LP characteristics between TBLA and RL. Receiver operating characteristic (ROC) analysis identified optimal diagnostic cut-offs, and sensitivity, specificity, and accuracy were calculated. Results: A total of 41 TBLA cases and 45 RL cases were included. Compared with the TBLA group, the RL group exhibited increased proportions of CD4⁺ T cells and B cells, and decreased proportions of CD8⁺ T cells, natural killer (NK) cells, and natural killer T (NKT) cells in LNPF. Among single parameters, the CD4/CD8 ratio demonstrated the highest diagnostic performance for TBLA, with sensitivity of 88.89%, specificity of 70.73%, and accuracy of 80.23%. Among three-parameter combinations, the CD4⁺ T cell, CD8⁺ T cell, and NK cell ratio combination achieved optimal diagnostic performance, with sensitivity of 80.5%, specificity of 86.7%, and accuracy of 82.6%.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.