Evidence map›Paper›PMID 40989710›Full record

ArticleClinical kidney journal2025

Association between air pollution and transplant outcomes in kidney transplant recipients: a systematic review and meta-analysis.

Mustafa Guldan, Lasin Ozbek, Derya Goksu Fidan, Ibrahim Gulmaliyev, Aladin Rustamov, Mehmet Kanbay

Abstract read
In one paragraph

Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mustafa GuldanDepartment of Medicine, Koc University School of Medicine, Istanbul, Turkey.
Lasin OzbekDepartment of Medicine, Koc University School of Medicine, Istanbul, Turkey.
Derya Goksu FidanDepartment of Medicine, Koc University School of Medicine, Istanbul, Turkey.
Ibrahim GulmaliyevDepartment of Medicine, Koc University School of Medicine, Istanbul, Turkey.
Aladin RustamovDepartment of Medicine, Koc University School of Medicine, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-1297-0675
Mehmet KanbayDepartment of Medicine, Section of Nephrology, Koc University School of Medicine, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Emerging evidence suggests that ambient air pollution may adversely affect long-term outcomes in kidney transplant recipients; however, quantitative estimates across clinical endpoints remain limited. This meta-analysis aimed to systematically evaluate the association between air pollution exposure and mortality, graft failure, and rejection risk in kidney transplant populations. Methods: A systematic database search was carried out across the databases of the Cochrane Library, Web of Science, Scopus, and PubMed until the 1 May 2025. Research that evaluated the impact of air pollution, particularly PM₂.₅, PM₁₀, NO₂, O₃, and other ambient pollutants, on graft survival in kidney transplant recipients were evaluated. Hazard ratios (HR) were extracted or recalculated for all-cause mortality, death-censored graft failure, and graft rejection per 10 µg/m³ increase in particulate matter concentration. Results: After screening 6209 records, a total of six studies involving populations of adult kidney transplant recipients from the USA, UK, South Korea, and Taiwan were included in the meta-analysis. Exposure to ambient air pollution was significantly associated with increased all-cause mortality among kidney transplant recipients [pooled HR 1.61; 95% confidence intervals (CI) 1.01-2.58], as well as higher risks of death-censored graft failure (HR 1.25; 95% CI 1.04-1.50) and graft rejection (HR 1.35; 95% CI 1.09-1.69) per 10 µg/m³ increment in particulate matter concentration. Substantial heterogeneity was observed across studies, particularly for mortality ( Conclusion: Ambient air pollution exposure is associated with increased risks of mortality, graft failure, and rejection in kidney transplant recipients, highlighting air pollution as a modifiable environmental risk factor that may have important implications for long-term transplant outcomes.

Indexed as

air pollutionallograft rejectioncardiovascular mortalitygraft survivalkidney transplantation

Identifiers

PMID40989710
PMCPMC12451696

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.